Fig. 2

Step by step procedure execution of combined laser therapy and technique parameters. A Representative ETDRS map illustrating SD-OCT thickened zone (light pinkcolor) with SRD (*) involving CST, inner and partial outer subfield map. Step 1 (white): SP laser application single shots performing two or three circumferential arc precisely placed 360º around the foveal center, at a distance ranging from 500 µm far away from center foveola till 1000 µm. Step 2 (red): additional Pascal^® SP multiple full-grid spots were applied in a 1.100–1.600 radius from foveal center (Pascal^® octants grid pattern) which includes 56 spots simultaneously triggered on mode A (twice triggered) switched with 56 spots simultaneously triggered on mode B (twice triggered). Step 3 (yellow): eight extra-segmented 14 number spots of SP laser (twice trigged each) are performed outside the 1600-radius area, achieving a laser treated area that has approximately 1850 radius placed 360º around previous Pascal^® SP multiple full-grid spots marks. Step 4 (purple): EpM-SDL was applied sweeping (2 times) the posterior pole at a 3000 µm radial extension from the foveal center covering 6 mm by 6 mm square area, sparing the 300 µm distance from it and overlapping the SP laser-treated areas. B Technique parameters table: Pascal^® SP and EpM algorithm titration of each (power of mark of laser spot, laser duration and size of spot) and laser treatment mode (power, location and mean number of shots)