Fig. 2

OCT for central diabetic macular edema (DME) treated with a suprachoroidal injection of triamcinolone and intravitreal Ziv-aflibercept. A Central DME with increased central macular thickness (CMT) with intraretinal cystic changes and hard exudates. B Four weeks after suprachoroidal injection of triamcinolone and intravitreal injection, Ziv-aflibercept reduced CMT and partially resolved intraretinal cysts. C Eight weeks after the first injection, the CMT increased, and intraretinal cystic changes reformed. At this point, the injection combination is repeated. D Four weeks after the second injection, a reduction in CMT and resolution of central intraretinal cysts were detected. E Eight weeks after the second injection, the CMT increased, and central intraretinal cystic changes reformed. At this point, the injection combination is repeated for the third time. F Four weeks after the third injection, a reduction in CMT and partial resolution of central intraretinal cysts were detected. G Eight weeks after the third injection, the CMT increased, and there was a slight reformation of the central intraretinal cyst