Figure 8

OCTA and FA of CNV in Neovascular AMD. (A) The right eye of a 63 year old Caucasian man with choroidal neovascularization (CNV) due to neovascular age-related macular degeneration (AMD) using the Angiovue optical coherence tomography angiography (OCTA) software of the RTVue XR Avanti (Optovue, Inc., Fremont, CA). (A1) 3 x 3 mm OCT angiogram segmented so both the choriocapillaris and the outer retina are shown. Two nets of abnormal vessels are shown surrounded by relatively homogenous choriocapillaris. The abnormal vessels exist both below and above Bruch’s membrane (in the outer retina). (A2-3) En-face structural OCT with a red line corresponding to a 12 mm highly sampled OCT b-scan (cropped to 3 mm) through the macula. The OCT b-scan demonstrates a retinal pigment epithelial detachment (RPED), subretinal fluid, an intraretinal cyst, and hyper-reflective material characteristic of CNV. (A4-6) Fluorescein angiography (FA) early, intermediate, and late frames showing increasing hyper-fluorescence and staining of the CNV. (B) The left eye of an 89 year old Caucasian woman with CNV type three (retinal angiomatous proliferation, RAP) due to neovascular AMD using the Angiovue OCTA software of the RTVue XR Avanti (Optovue, Inc., Fremont, CA). (B1) 6 x 6 mm OCT angiogram segmented at the outer retina showing a round RAP lesion (yellow arrow). A feeder vessel from a retinal vessel was noted (not shown). (B2) Color fundus photo demonstrating hemorrhage in the region of the RAP lesion. (B3) 6 mm highly sampled OCT b-scan through the macula shows subretinal and intraretinal fluid and a round ball of hyper-reflective tissue above a serous RPED. (B4-6) FA early, intermediate, and late frames showing increasing hyper-fluorescence and pooling in the CNV.