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Table 5 Genetic testing costs for genes as per Yu et al. [4]

From: A Value-Based Medicine cost-utility analysis of genetic testing for neovascular macular degeneration

CPT code Explanation Multiplier NLA Total NLA
83891 DNA Isolation 1 $5.7 $5.7
83900 Amplification of patient nucleic acid, multiplex, first two nucleic sequences 1 $47.8 $47.8
83901 Amplification of patient nucleic acid, multiplex, each additional acid sequence 10 $23.7 $237
83892 Digestion of amplified DNA with restriction endonuclease enzyme, each 2 $5.7 $11.4
83914 Mutation identification by enzymatic ligation or primer extension, single segment, each segment [e.g. oligonucleotide ligation assay (OLA), single base chain extension (SBCE), or allele-specific primer extension (ASPE)] 15 $23.7 $356
83912 Interpretation and report 1 $5.7 $5.7
83896 Nucleic acid probe, each 15 $5.7 $85
83903 Molecular diagnostics; mutation scanning by physical properties, single segment, each 15 $23.7 $356
83908 Molecular diagnostics; signal amplification of patient nucleic acid, each nucleic acid sequence 15 $23.7 $356
Cost per patient tested $1461
Adjusted for a genetic testing age of 65 years and ranibizumab. Total treatment age of 75 years (compounded at 3 % annually) $1906
Including the $299 incremental yearly ophthalmic examination and optical coherence. Total tomogram in the 20 % of patients with a high-risk genetic score [4] $2205
  1. CPT Current Procedural Terminology, published by the American Medical Association, NLA National Limitation Amount, all cost in 2012 US nominal dollars