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Table 1 Comparison of methods for early detection of CNV

From: Early detection of age related macular degeneration: current status

Method Central visual field evaluated Description of method Pros Cons
OCT NA High resolution cross-sectional imaging of the retina Sensitivity for detection of intra- and sub-retinal fluid in small quantities Not yet portable, necessitating clinic visits
Amsler grid 20° A chart consisting of a 10 cm square with a grid and a central spot for fixation Readily available
Convenient to use
Variable sensitivity
Near visual acuity NA Near vision chart Readily available
Convenient to use
Sensitivity and specificity were not studied
Preferential hyperacuity perimetry (PHP) home device 14° Quantification of perceived distortions by the patient Smaller decline in visual acuity compared to standard care Cost
Shape-discrimination hyperacuity (SDH) smartphone application NA Shape discrimination tasks testing a patient’s ability to detect visual distortion Convenient to use
May differentiate between advanced and intermediate AMD
Large scale studies still underway at the time of this writing
Macular mapping test (MMT) 18° Tests residual function while providing a quantitative score, allowing for monitoring of disease progression May be useful to monitor progression of AMD Not readily available
No large scale studies
Noisefield perimetry NA Flickering dots are shown at high frequency. Patients report abnormalities in background noisefield Relatively high sensitivity and specificity for detection of AMD, more at advanced stages Not readily available
No large scale studies
  1. CNV choroidal neovascularization, OCT optical coherence tomography, AMD age related macular degeneration