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Table 1 Comparative table showing the structural differences between the three fusion proteins available for treatment of retinal diseases

From: Fusion proteins for treatment of retinal diseases: aflibercept, ziv-aflibercept, and conbercept

  Aflibercept Ziv-aflibercept Conbercept
Structure Fusion of the second domain of VEGFRs 1 and the third domain of VEGFR 2 to the Fc portion of human IgG1 Fusion of the second domain of VEGFRs 1 and the third domain of VEGFR 2 to the Fc portion of human IgG1 Fusion of the second domain of VEGFR1 and the third and fourth domains of VEGFR2 to the Fc portion of human IgG1
Mechanism of action Binds to all isoforms of VEGF-A, VEGF-B and PIGF Binds to all isoforms of VEGF-A, VEGF-B and PIGF Binds with all isoforms of VEGF-A, VEGF-B, VEGF-C and PIGF
Concentration 40 mg/ml 25 mg/ml 10 mg/ml
Binding affinity to VEGF-A (165) Kd 0,49 Pm Kd 0,49 Pm Kd 0,5 Pm
Molecular weight 115 kDa 115 kDa 143 kDa
Osmolarity 286 mOsm 1000 mOsm Not published
Half-life 7, 1 days 7, 1 days 4, 2 days (rabbits)