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Table 9 Macroeconomic (ROI) for ranibizumab therapy for neovascular AMD using the societal cost perspective, combined-eye model

From: The comparative effectiveness and cost-effectiveness of ranibizumab for neovascular macular degeneration revisited

Cost perspective

Direct ophthalmic medical cost per patient

Annual # of cases

Total direct ophthalmic medical costs

Net cost/case with direct ophthalmic costs

12-year financial gain

MARINA—costs off-setting the s direct ocular medical costs

$79,056

178,000

$14.1 billion

(−$282,517)

$50.2 billion

MARINA GDP gain

$79,056

178,000

$14.1 billion

(−$165,842)

$29.5 billion

  1. ROI return-on-investment referent to the direct medical costs associated with ranibizumab administration, GDP Gross Domestic Product, MARINA minimally classic/occult trial of the anti-VEGF antibody ranibizumab in the treatment of neovascular age-related macular degeneration (AMD)