Table 1 Pre-defined inclusion and exclusion criteria

Inclusion criteria

 Able to provide informed consent

 Age 18 years or older

 Clear ocular media

 Baseline IOP of 21 mmHg or less with or without pressure-lowering drops in patients previously treated with corticosteroids

 Snellen visual acuity between 20/40 and 20/300

 CRT on SD-OCT ≥350 μm at the time of switch to IVE

 Minimum of 4 treatments for DME, with at least 3 being anti-VEGF intravitreal injections (excluding IAI), administered within the 6 months prior to IAI switch

 <15% decrease in CRT during the 6 months prior to IAI switch (worsening)

 3 or more IAI within 6 months after switch

Exclusion criteria

 Previous IAI in the study eye

 History of systemic anti-VEGF use