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Table 5 A review of previous studies using gamma knife radiosurgery for uveal melanoma

From: Gamma knife radiosurgery for the treatment of uveal melanoma and uveal metastases

Study Eyes Radiation dose (Gy) Follow-up (months) Visual acuity Complications Survival (%)
Before After Radiation retinopathy (%) Radiation neuropathy (%) Neovascular glaucoma (%) Neovascularization Radiation maculopathy (%) Vitreous hemorhage Enucleation (%)
Modorati et al. [1] GKR 78 50 (n = 7) 40 (n = 21) 35 (n = 47) at 50% isodose 31.3 (median) 0.3 (0.05–0.8) 0 (0–0.05) 13.5 15.5 18.7      88.8% at 3 years and 81.9% at 5 years
Joye et al. [2] GKR 23 21.7 at 50% isodose 41.5 (median) 20/20-CF 20/20-NLP 8.7 13.0 17.4 8.7   8.7   91.3%
Marchini et al. [3] GKR 12 55 ± 10 Gy to 60–90% isodose 6 (median) Not reported Not reported 8.33 8.33 8.33   8.33    Not reported
Chan et al. [4] GKR 6 25 at 50% isodose 24 (median) 20/40–20/80 20/50-LP 16.7 16.7 16.7      100%
Dinca et al. [5] GKR 170 50–70 (n = 24) 45 (n = 71) 35 (n = 62) at 50% isodose 63.5 (median) Patients with more than three lines decrease in VA at 5 years 45% (35 Gy), 89% (45 Gy), 93% (50–70 Gy)   25.81–41.67 12.68–20.83 8.06–20.82      5-year survival rates: 64% for 35 Gy, 62.71% for 45 Gy, 63.6% for 50–70 Gy
Sarici et al. [6] GKR 50 30 at 50% isodose 40 (median) NR visual acuity decreased significantly after treatment (p < 0.0001)   24 14 14      87%
Sikuade et al. [7] GKR 85 35 at 50% isodose 39 (mean) Not recorded 33% better than 6/60. 65% loss of ≥3 Snellen lines NR        84%
Bellman et al. [8] GKR 5 50 maximum average dose 7.3 (median) 20/20–20/320 20/20-CF NR        No deaths
Furdova et al. [9] GKR 96 49.0 maximum average dose 24 (mean) 16% ≥ 20/40, 58% < 20/40 ≥ 20/200, 26% < 20/200 11% ≥ 20/40, 47% < 20/40 ≥ 20/200, 42% < 20/200        11.5 Tumor local control was successful in 80% of patients in 5 years interval after stereotactic radiosurgery
Suesskind et al. [10] SDRT 60 25 at 50% isodose 33.7 (median) 20/20-LP Median loss of −18 Snellen lines 42 24 15      83%
Kang et al. [11] GKR 22 45.6 at 50% isodose 67 (median) LP to 1.2 NLP to 0.9 22.7   9.1      90.9%
Eibl-Lindner [12] frameless, single-session, image-guided robotic radiosurgery 217 20.3 at the 69% isodose 29.6 (mean) A total of 104 patients presented with functional vision (defined as visual acuity ≥0.3) before treatment Functional vision maintained in 30.9% of patients 13.4   15.2      Actuarial disease-specific survival was 84.8% (95% CI 77.0–90.1%) at 3 years and 78.4% (95% CI 67.1–86.2%) at 5 years
Haas et al. [13] GKR 32 50 at 50% isodose 38 (mean) 20% ≤ 20/400 78% ≤ 20/400 84   47      Metastasis free 94%, overall NR
Langmann et al. [14] GKR 60 50–70 isodose 50–80% 16–94 (range) Not recorded Not recorded   20 35      Metastasis free 85%, overall NR
Simonova et al. [15] GKR 81 31.4 minimum dose 32 (median) Not recorded Not recorded   12.3 25      70.4%
Fakiris et al. [16] GKR 19 40 isodose 50% 40 (median) Not recorded Not recorded   11 0      86% at 5 years
Zehetmayer et al. [17] GKR 62 45–70 isodose 50% 23.8 (median) 56.8% ≥ 20/200 21% ≥ 20/200 17.3 19.8 12.3      84% at 3 years
Current study GKR 11 25.0 ± 3.36 at 50% isodose 19.74 ± 10.4 (median) 20/30-CF 20/30-LP 18.2 9 0      72.7%
  1. NR not recorded