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Fig. 6 | International Journal of Retina and Vitreous

Fig. 6

From: Dexamethasone implant in silicone oil: in vitro behavior

Fig. 6

a Inhibitory effect on TNF-α levels from the implant in 5000cs SO. A model of stimulation and inhibition was standardized using LPS-stimulated PBMNC (as a positive stimulation control) and DEX (as a positive inhibition control). PBMNC were also exposed to each one of the samples acquired from the implant in SO-5000 at different times to assess the inhibitory effects over TNF-α levels in every sample. As a negative stimulation control, PBMNC were exposed to RPMI-1640 without any other stimuli. Results are presented in a bar graph where the mean value ± SD is reported in pg/mL. Mann–Whitney U test was used for statistical comparisons. A value of p < 0.05 was considered statistically significant. SO-5000 5000cS silicone oil, LPS lipopolysaccharide, PBMNC peripheral mononuclear blood cells, DEX dexamethasone, SD standard deviation, WO without, h hours, w weeks, m months. *p < 0.05; **p < 0.01; ***p < 0.001. b Inhibitory effect on TNF-α levels from the implant in Heavy SO. A model of stimulation and inhibition was standardized using LPS-stimulated PBMNC (as a positive stimulation control) and DEX (as a positive inhibition control). PBMNC were also exposed to each one of the samples acquired from the implant in D-68 at different times to assess the inhibitory effects over TNF-α levels in every sample. As a negative stimulation control, PBMNC were exposed to RPMI-1640 without any other stimuli. Results are presented in a bar graph where the mean value ± SD is reported in pg/mL. Mann–Whitney U test was used for statistical comparisons. A value of p < 0.05 was considered statistically significant. D-68 heavy silicone oil, LPS lipopolysaccharide, PBMNC peripheral mononuclear blood cells, DEX dexamethasone, SD standard deviation, WO without, h hours, w weeks, m months. *p < 0.05; **p < 0.01; ***p < 0.001

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