Fig. 2

Photographs and intraoperative OCT (iOCT) images obtained during gene therapy surgery. a, b “Fleur-de-lis” sign during initial subretinal injection procedure (pink circle) with (a) hypereflective image due to air bubble wall reflection—double hypereflective sign (yellow circle). c, diOCT image obtained during final step of subretinal injection with visible open retinotomy (arrow) and associated transmitted hypereflective image (arrowhead)