Fig. 4

Photographs and intraoperative OCT (iOCT) images obtained during gene therapy surgery. aiOCT image obtained after subretinal injection with directional reflectivity image in the posterior surface of the bleb (asterix) with associated RPE separation (arrow). b Intraoperative OCT image obtained after subretinal injection showing a suprachoroidal fluid (arrowhead), associated with retinal schisis (arrowhead and yellow arrow) and foveal inversion (yellow asterix). c Mirror artifact with the iOCT image focus in the attached retina and in the retinal bleb (red asterix). d Retinal fold present at the peripheral retina (red arrow)