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Table 3 Results of multivariable regression models for the SLE group—dependent variable: pRNFL thickness

From: Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography

Model

Coefficient estimate

95% confidence interval

p-value

Dependent variable: pRNFL thickness G

 Age (years)

− 3.02

− 4.91 to − 1.13

0.002

 Axial length (mm)

− 3.98

− 6.34 to − 1.62

0.001

 Calcium channel blocker

− 10.66

− 18.56 to − 2.77

0.009

 Anticoagulant

− 6.71

− 12.42 to − 1.00

0.022

Dependent variable: pRNFL thickness TS

 Age (years)

− 3.38

− 6.55 to − 0.22

0.037

 Axial length (mm)

− 4.12

− 8.13 to − 0.12

0.044

Dependent variable: pRNFL thickness T

 Sjogren syndrome

− 10.36

− 19.38 to − 1.35

0.025

Dependent variable: pRNFL thickness TI

 IOP (mm Hg)

− 2.15

− 3.60 to − 0.71

0.004

 Calcium channel blocker

− 17.97

− 32.64 to − 3.30

0.017

 Anticoagulant

− 15.08

− 25.84 to − 4.31

0.007

 Statin

− 13.94

− 25.73 to − 2.15

0.021

Dependent variable: pRNFL thickness NI

 Axial length (mm)

− 9.03

− 14.59 to − 3.47

0.002

 Anticoagulant

− 17.16

− 31.56 to − 2.76

0.020

 Statin

− 18.56

− 34.09 to − 3.03

0.020

Dependent variable: pRNFL thickness N

 Body mass index (kg/m2)

− 0.80

− 1.58 to − 0.01

0.046

 ACE inhibitor

− 10.03

− 18.61 to − 1.45

0.023

Dependent variable: pRNFL thickness NS

 Axial length (mm)

− 5.47

− 9.46 to − 1.47

0.008

 Calcium channel blocker

− 20.07

− 34.01 to − 6.12

0.006

 Anticoagulant

− 11.34

− 21.99 to − 0.69

0.037

 Corticosteroid (mg)

0.12

0.05 to 0.18

0.001

  1. Age: for each 10-year increase. Corticosteroid is expressed as the daily dose of prednisone equivalent. p-values were obtained by linear regression models
  2. ACE angiotensin-converting enzyme, G global, IOP intraocular pressure, N nasal, NI nasal inferior, NS nasal superior, pRNFL peripapillary retinal nerve fiber layer, SLE systemic lupus erythematosus, T temporal, TI temporal inferior, TS temporal superior