Fig. 1

Localization of epiretinal proliferation and retinal abnormalities. a The standard ETDRS quadrants dividing the macula into central fovea, inner macula, and outer macula. C: Central foveal quadrant, In S: Inner superior macula, In N: Inner nasal macula, In I: Inner inferior macula, In T: Inner temporal macula, OS: Outer superior macula, ON: Outer nasal macula, OI: Outer inferior macula, OT: Outer temporal macula. b Presence of epiretinal proliferation (ERP) was localized on optical coherence tomography (OCT) scans using the 9 ETDRS quadrants. The second row shows the rate of eyes displaying ERP within the 9 ETDRS sectors in all included eyes (c), in eyes with vitreoretinal interface (VRI) pathologies (d) and in eyes treated for different retinal diseases (e). The most frequently involved ETDRS sector was the 1-mm central circle, followed by the inner temporal and inner nasal quadrants. The third row shows the rate of eyes with retinal abnormalities including partial or full-thickness retinal defect, epiretinal membrane, intraretinal cysts, pigmentary epithelium detachment, and outer retinal layers disruption, within the nine ETDRS sectors, among all included eyes (f), in eyes with vitreoretinal interface pathologies (g) and in eyes treated for different retinal diseases (h). Localization of ERP within the 9 ETDRS sectors was strongly correlated with the presence in the same sector of any retinal lesion in all the studied eyes (r = 0.962; P < 0.0001), in the VRI pathologies group (r = 0.938; P = 0.0002) and in the retinal diseases group (r = 0.909; P = 0.001)