Fig. 5From: Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profileRetinal findings by histology with hematoxylin and eosin staining seven days after intravitreal injection of ramucirumab. a control eye. b–d IVT injection of 250 µg ramucirumab. e–h IVT injection of 500 µg ramucirumab. Ganglion cells: focal areas of vacuolization (*). Inner plexiform and nuclear layers showing focal vacuolization. Outer plexiform layer: intact. Outer nuclear layer: artifactual findings (red arrows)Back to article page