Table 1 Comparative analysis of full-field electroretinography (ERG) responses
From: Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profile
Rods | Combined A | Combined B | Cone A | Cone B | Flicker | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | Baseline | Follow-up | P-value | |
C1–C4 | ||||||||||||||||||
OD | 83.1 (54.0–119.0) | 155.5 (103.0–162.0) | 0.0679 | 42.5 (36.7–70.5) | 52.3 (44.7–61.9) | 0.4652 | 146.0 (84.3–165.0) | 202.5 (119.0–241.0) | 0.0679 | 10.1 (6.2–15.3) | 9.5 (7.8–12.8) | 0.4652 | 105.0 (61.7–115.0) | 94.8 (63.7–118.0) | 0.9999 | 66.0 (48.3–77.8) | 76.5 (42.3–94.1) | 0.4652 |
OS | 69.8 (34.2–134.0) | 185.5 (153.0–251.0) | 0.0679 | 36.5 (23.4–71.7) | 72.3 (45.1–80.5) | 0.0679 | 135.0 (80.4–163.0) | 227.5 (188.0–301.0) | 0.0679 | 8.6 (6.3–11.7) | 8.9 (5.4–17.4) | 0.4652 | 97.7 (60.5–111.0) | 102.3 (70.1–176.0) | 0.0679 | 54.1 (32.1–75.2) | 95.1 (64.7–115.0) | 0.0679 |
C5–C8 | ||||||||||||||||||
OD | 108.2 (16.9–160.0) | 154.5 (135.0–205.0) | 0.0679 | 50.8 (10.5–62.8) | 62.0 (60.1–64.9) | 0.0679 | 146.0 (27.8–181.0) | 178.0 (151.0–205.0) | 0.0679 | 7.2 (1.8–10.6) | 10.4 (7.9–13.6) | 0.0679 | 63.8 (12.7–86.3) | 99.7 (65.8–127.0) | 0.1441 | 66.7 (6.24–81.0) | 79.3 (72.1–104.0) | 0.0679 |
OS | 115.7 (51.6–207.0) | 142.5 (84.0–188.0) | 0.5807 | 53.1 (28.4–87.1) | 61.7 (40.3–69.8) | 0.715 | 148.0 (79.2–236.0) | 179.0 (118.0–217.0) | 0.4652 | 8.5 (5.9–11.0) | 9.3 (7.2–13.4) | 0.2733 | 69.6 (53.7–100.0) | 74.1 (71.4–129.0) | 0.1441 | 67.5 (25.7–110.0) | 61.9 (50.5–82.2) | 0.715 |
C9–C11 | ||||||||||||||||||
OD | 101.0 (37.3–104.0) | 101.0 (93.5–156.0) | 0.285 | 44.7 (40.2–60.3) | 58.7 (39.7–68.8) | 0.9999 | 134.0 (57.8–160.0) | 169.0 (147.0–234.0) | 0.1088 | 9.1 (7.5–9.5) | 10.1 (8.9–11.9) | 0.1088 | 86.2 (63.9–99.8) | 108.0 (90.9–132.0) | 0.1088 | 61.9 (42.7–72.0) | 63.5 (58.4–69.0) | 0.593 |
OS | 117.0 (26.9–119.0) | 133.0 (96.7–179.0) | 0.1088 | 46.7 (35.5–51.4) | 63.2 (33.3–82.3) | 0.285 | 113.0 (54.7–169.0) | 208.0 (125.0–238.0) | 0.1088 | 11.3 (5.7–11.8) | 11.6 (11.2–14.8) | 0.285 | 85.7 (52.1–110.0) | 91.6 (79.7–107.0) | 0.285 | 56.6 (34.0–89.1) | 88.4 (68.8–89.6) | 0.1088 |
C12–C16 | ||||||||||||||||||
OD | 105.0 (93.3–163.0) | 113.0 (94.7–170.0) | 0.9999 | 57.7 (49.2–62.7) | 42.1 (37.5–50.3) | 0.285 | 143.0 (133.0–154.0) | 127.0 (126.0–173.0) | 0.9999 | 7.4 (7.0–7.6) | 8.1 (4.5–8.3) | 0.9999 | 74.1 (60.5–86.2) | 52.7 (48.4–89.7) | 0.285 | 50.9 (49.4–71.7) | 51.6 (33.4–71.7) | 0.9999 |
OS | 114.0 (99.5–175.0) | 108.0 (108.0–110.0) | 0.593 | 58.6 (55.6–69.1) | 43.3 (34.9–46.8) | 0.1088 | 165.0 (134.0–177.0) | 131.0 (128.0–132.0) | 0.1088 | 8.6 (8.4–11.1) | 6.7 (5.0–7.1) | 0.1088 | 95.7 (65.7–99.6) | 59.0 (51.2–75.3) | 0.1088 | 71.6 (57.6–84.0) | 48.6 (45.0–56.5) | 0.1088 |