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Table 2 Serum and aqueous humor osmolarity

From: Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profile

 

Blood osmolarity

Aqueous humor osmolarity

Baseline

Follow-up

P value

Baseline

Follow-up

P value

C1–C4—24 h

338.5 (270.0–358.0)

337.0 (335.0–357.0)

0.9999

300.0 (300.0–300.0)

331.0 (320.0–342.0)

0.9999

C5–C9—7 days

331.0 (324.0–355.0)

324.5 (324.0–325.0)

0.1797

332.0 (319.0–339.0)

315.5 (246.0–329.0)

0.0679

C9–C11—24 h

307.5 (281–334.0)

309.0 (260.0–322.0)

0.1797

319.0 (212.0–323.0)

331.0 (323.0–381.0)

0.1088

C12–C16—7 days

NA

NA

NA

323.0 (309.0–338.0)

316.0 (305.0–435.0)

0.9999

  1. Serum and aqueous humor osmolarity in rabbits injected with ramucirumab in the right eye at baseline and follow-up. Values of osmolarity are presented as median (range). Statistical analysis was performed using Wilcoxon signed-rank test. C1–C4 (500 µg group with 24 h of follow-up); C5–C8 (500 µg group with 7 days of follow-up); C9–C11 (250 µg group with 24 h of follow-up); C12–C16 (250 µg group with 7 days of follow-up—blood osmolarity not available). NA not available due to technical problems