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Table 2 Serum and aqueous humor osmolarity

From: Preclinical assessment of intravitreal ramucirumab: in vitro and in vivo safety profile

  Blood osmolarity Aqueous humor osmolarity
Baseline Follow-up P value Baseline Follow-up P value
C1–C4—24 h 338.5 (270.0–358.0) 337.0 (335.0–357.0) 0.9999 300.0 (300.0–300.0) 331.0 (320.0–342.0) 0.9999
C5–C9—7 days 331.0 (324.0–355.0) 324.5 (324.0–325.0) 0.1797 332.0 (319.0–339.0) 315.5 (246.0–329.0) 0.0679
C9–C11—24 h 307.5 (281–334.0) 309.0 (260.0–322.0) 0.1797 319.0 (212.0–323.0) 331.0 (323.0–381.0) 0.1088
C12–C16—7 days NA NA NA 323.0 (309.0–338.0) 316.0 (305.0–435.0) 0.9999
  1. Serum and aqueous humor osmolarity in rabbits injected with ramucirumab in the right eye at baseline and follow-up. Values of osmolarity are presented as median (range). Statistical analysis was performed using Wilcoxon signed-rank test. C1–C4 (500 µg group with 24 h of follow-up); C5–C8 (500 µg group with 7 days of follow-up); C9–C11 (250 µg group with 24 h of follow-up); C12–C16 (250 µg group with 7 days of follow-up—blood osmolarity not available). NA not available due to technical problems