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Fig. 1 | International Journal of Retina and Vitreous

Fig. 1

From: Near-infrared reflectance imaging of neovascularization in proliferative diabetic retinopathy

Fig. 1

NIR sequence of IRMA growing into NVE over 4 years. Baseline NIR a shows hyporeflective irregular vessels arising from the inferior temporal vein (box). Corresponding fluorescein angiography b in early (top) and late (bottom) frames is in accordance with IRMA as no late leakage. Note the associated areas of non-perfusion (✢). The patient was started on panretinal photocoagulation as there were other areas of proliferation. At 6 months follow-up, a change in morphology with enlargement of the complex (box) in the NIR image can be observed (c). Matching color fundus photograph d and clinical examination were compatible with NVE. Laser treatment was continued and on a subsequent visit, the vascular complex was less apparent, suggesting regression e and the angiogram showed only mild late leakage (f, box). The NVE remained stable until 2 years from (f), when significant progression was identified in the NIR image g with new hyporeflective fronds (box), in accordance with NVE reactivation and growth. Complementary fluorescein angiography h shows late leakage with 2 NVE areas, clearly more active than in (f). With additional laser treatment, NIR i 4 months from g shows regression and thinning of the hyporeflective structures reflecting NVE regression, which was corroborated by clinical examination

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