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Table 3 Vascular density in optic nerve head (ONH) of normal subjects and subtypes of diabetic retinopathy (N = 176)

From: Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography

Groups
VD/
Reference group
NL (37 eyes)
Mean ± SD (%)
NDR (35 eyes)
Mean ± SD (%)
NPDR (58 eyes)
Mean ± SD (%)
PDR (46 eyes)
Mean ± SD (%)
p-value Kruskal–Wallis test
Whole image (median)
NL
NDR
NPDR
58.26
(53.54–61.60)
56.90
(49.73–61.62)
0.145*
55.11
(46.48–59.59)
0.014*
0.398*
55.48
(49.94–55.48)
< 0.001*
0.018*
0109*
0.002
Whole disc
NL
NDR
NPDR
52.39 ± 0.96 53.15 ± 0.96
1.000
49.66 ± 1.90
0.746
0.767
50.03 ± 1.62
0.033
0.039
0.191
0.018
N-disc
NL
NDR
NPDR
50.35 ± 1.87 52.76 ± 1.37
0.958
50.23 ± 2.50
0.862
0.996
54.66 ± 2.30
0.995
0.869
0.683
0.684
IN-disc
NL
NDR
NPDR
56.74 ± 3.14 59.35 ± 2.10
0.582
54.33 ± 3.81
0.993
0.345
57.66 ± 2.24
0.833
0.136
0.913
0.182
IT-disc
NL
NDR
NPDR
52.35 ± 1.44 52.91 ± 1.94
0.869
45.51 ± 3.04
0.130
0.560
46.15 ± 2.75
0.024
0.823
0.823
0.022
T-disc
NL
NDR
NPDR
49.91 ± 1.80 48.34 ± 1.36
0.498
46.05 ± 2.05
0.145
0.945
41.25 ± 1.78
< 0.001
0.004
0.006
< 0.001
ST-disc
NL
NDR
NPDR
51.47 ± 2.18 48.66 ± 2.11
0.648
46.92 ± 2.04
0.962
0.850
45.42 ± 2.70
0.463
0.997
0.679
0.426
SN-disc
NL
NDR
NPDR
57.13 ± 2.20 60.59 ± 2.25
0.419
57.10 ± 2.16
0.999
0.398
55.13 ± 2.45
0.996
0.260
0.981
0.272
Whole RPC
NL
NDR
NPDR
62.24
(56.78–67.02)
59.68
(55.13–65.35)
0.006
60.07
(50.83–64.37)
0.009*
0.991*
59.35
(51.42–65.48)
< 0.001*
0.036*
0.041*
< 0.001*
N-RPC
NL
NDR
NPDR
60.07
(53.26–67.12)
57.33
(50.30–64.84)
< 0.001*
59.41
(36.69–53.39)
0.087*
0.631*
58.66
(44.94–66.08)
0.001*
0.112*
0.073*
0.011*
IN-RPC
NL
NDR
NPDR
53.75 ± 1.00 60.22 ± 1.26
< 0.104
60.31 ± 2.01
0.031
0.997
60.81 ± 1.28
0.006
0.836
0.884
0.0001
IT-RPC
NL
NDR
NPDR
64.48 ± 0.92 63.64 ± 0.75
0.331
60.94 ± 1.21
0.006
0.486
61.11 ± 1.04
< 0.001
0.037
0.427
< 0.001
T-RPC
NL
NDR
NPDR
62.45 ± 0.78 60.84 ± 0.73
0.648
58.95 ± 0.70
0.911
0.911
58.00 ± 1.86
< 0.001
0.030
0.072
0.001
ST-RPC
NL
NDR
NPDR
62.63 ± 1.07 61.45 ± 1.11
0.622
59.66 ± 2.16
0.993
0.993
55.13 ± 2.45
0.006
0.196
0.206
0.012
SN-RPC
NL
NDR
NPDR
62.34
(49.65–47.35)
59.06
(50.16–59.06)
0.099
60.38
(55.23–68.06)
0.087
0.686*
58.46
(35.64–68.39)
0.016
0.336*
0.517*
0.047
Peripapillary CC flow (median)
NL
NDR
NPDR
7.57
(7.19–7.89)
7.63
(6.81–7.84)
0.890*
7.50
(1.74–8.80)
0.023*
0.024*
7.43
(1.5–7.79)
0.003*
0.004*
0.283*
0.003
Peripapillary CC flow- /area2 mm radius
NL
NDR
NPDR
0.61
(0.58–0.63)
0.60
(0.56–0.62)
0.713*
0.60
(0.52–0.62)
0.009*
0.016*
0.59
(0.50–0.63)
0.001*
0.003*
0.482*
0.001
  1. P values less than 0.05 were considered statistically significant
  2. In the post-HOC analysis the reference groups were stated in the rows
  3. NDR: No diabetic retinopathy; NL: Normal; NPDR: Nonproliferative diabetic retinopathy; PDR: Proliferative diabetic retinopathy
  4. *Mann–Whitney test