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Table 3 Vascular density in optic nerve head (ONH) of normal subjects and subtypes of diabetic retinopathy (N = 176)

From: Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography

Groups

VD/

Reference group

NL (37 eyes)

Mean ± SD (%)

NDR (35 eyes)

Mean ± SD (%)

NPDR (58 eyes)

Mean ± SD (%)

PDR (46 eyes)

Mean ± SD (%)

p-value Kruskal–Wallis test

Whole image (median)

NL

NDR

NPDR

58.26

(53.54–61.60)

56.90

(49.73–61.62)

0.145*

55.11

(46.48–59.59)

0.014*

0.398*

55.48

(49.94–55.48)

< 0.001*

0.018*

0109*

0.002

Whole disc

NL

NDR

NPDR

52.39 ± 0.96

53.15 ± 0.96

1.000

49.66 ± 1.90

0.746

0.767

50.03 ± 1.62

0.033

0.039

0.191

0.018

N-disc

NL

NDR

NPDR

50.35 ± 1.87

52.76 ± 1.37

0.958

50.23 ± 2.50

0.862

0.996

54.66 ± 2.30

0.995

0.869

0.683

0.684

IN-disc

NL

NDR

NPDR

56.74 ± 3.14

59.35 ± 2.10

0.582

54.33 ± 3.81

0.993

0.345

57.66 ± 2.24

0.833

0.136

0.913

0.182

IT-disc

NL

NDR

NPDR

52.35 ± 1.44

52.91 ± 1.94

0.869

45.51 ± 3.04

0.130

0.560

46.15 ± 2.75

0.024

0.823

0.823

0.022

T-disc

NL

NDR

NPDR

49.91 ± 1.80

48.34 ± 1.36

0.498

46.05 ± 2.05

0.145

0.945

41.25 ± 1.78

< 0.001

0.004

0.006

< 0.001

ST-disc

NL

NDR

NPDR

51.47 ± 2.18

48.66 ± 2.11

0.648

46.92 ± 2.04

0.962

0.850

45.42 ± 2.70

0.463

0.997

0.679

0.426

SN-disc

NL

NDR

NPDR

57.13 ± 2.20

60.59 ± 2.25

0.419

57.10 ± 2.16

0.999

0.398

55.13 ± 2.45

0.996

0.260

0.981

0.272

Whole RPC

NL

NDR

NPDR

62.24

(56.78–67.02)

59.68

(55.13–65.35)

0.006

60.07

(50.83–64.37)

0.009*

0.991*

59.35

(51.42–65.48)

< 0.001*

0.036*

0.041*

< 0.001*

N-RPC

NL

NDR

NPDR

60.07

(53.26–67.12)

57.33

(50.30–64.84)

< 0.001*

59.41

(36.69–53.39)

0.087*

0.631*

58.66

(44.94–66.08)

0.001*

0.112*

0.073*

0.011*

IN-RPC

NL

NDR

NPDR

53.75 ± 1.00

60.22 ± 1.26

< 0.104

60.31 ± 2.01

0.031

0.997

60.81 ± 1.28

0.006

0.836

0.884

0.0001

IT-RPC

NL

NDR

NPDR

64.48 ± 0.92

63.64 ± 0.75

0.331

60.94 ± 1.21

0.006

0.486

61.11 ± 1.04

< 0.001

0.037

0.427

< 0.001

T-RPC

NL

NDR

NPDR

62.45 ± 0.78

60.84 ± 0.73

0.648

58.95 ± 0.70

0.911

0.911

58.00 ± 1.86

< 0.001

0.030

0.072

0.001

ST-RPC

NL

NDR

NPDR

62.63 ± 1.07

61.45 ± 1.11

0.622

59.66 ± 2.16

0.993

0.993

55.13 ± 2.45

0.006

0.196

0.206

0.012

SN-RPC

NL

NDR

NPDR

62.34

(49.65–47.35)

59.06

(50.16–59.06)

0.099

60.38

(55.23–68.06)

0.087

0.686*

58.46

(35.64–68.39)

0.016

0.336*

0.517*

0.047

Peripapillary CC flow (median)

NL

NDR

NPDR

7.57

(7.19–7.89)

7.63

(6.81–7.84)

0.890*

7.50

(1.74–8.80)

0.023*

0.024*

7.43

(1.5–7.79)

0.003*

0.004*

0.283*

0.003

Peripapillary CC flow- /area2 mm radius

NL

NDR

NPDR

0.61

(0.58–0.63)

0.60

(0.56–0.62)

0.713*

0.60

(0.52–0.62)

0.009*

0.016*

0.59

(0.50–0.63)

0.001*

0.003*

0.482*

0.001

  1. P values less than 0.05 were considered statistically significant
  2. In the post-HOC analysis the reference groups were stated in the rows
  3. NDR: No diabetic retinopathy; NL: Normal; NPDR: Nonproliferative diabetic retinopathy; PDR: Proliferative diabetic retinopathy
  4. *Mann–Whitney test