Table 1 Demographics, characteristics, and interventions of eyes with visual impairment from center-involved diabetic macular edema stratified by visual acuity response at one year following treatments
Characteristics | Overall (N = 226 Eyes) | Gain ≥ 10 Letters at 1 Year (N = 110 Eyes) | Gain < 10 Letters at 1 Year (N = 116 Eyes) | P Value* |
|---|---|---|---|---|
Demographics | ||||
 Age ≥ 60 years, n (%) | 78 (34.5) | 30 (27.3) | 48 (41.4) | 0.041 |
 Male, n (%) | 122 (54) | 66 (60) | 56 (48.3) | 0.112 |
 Severe NPDR to PDR stage, n (%) | 158 (69.9) | 75 (68.2) | 83 (71.6) | 0.638 |
 Previous macular laser photocoagulation, n (%) | 42 (18.6) | 13 (11.8) | 29 (25) | 0.019 |
 Previous PRP, n (%) | 63 (27.9) | 28 (25.5) | 35 (30.2) | 0.528 |
 Phakia, n (%) | 202 (89.4) | 102 (92.7) | 100 (86.2) | 0.115 |
Ocular characteristics at baseline | ||||
 Mean (SD) VA, letter | 51.8 (19.1) | 46 (21) | 57.3 (15.2) |  < 0.001 |
 VA ≥ 69 letters, n (%) | 63 (27.9) | 23 (20.9) | 40 (34.5) | 0.025 |
 Mean CSFT (SD), µm | 496.2 (145.2) | 513.9 (164.5) | 479.4 (122.6) | 0.159 |
 CSFT ≥ 400 µm | 163 (72.1) | 80 (72.3) | 83 (81.6) | 0.983 |
 ERM, n (%) | 28 (12.4) | 7 (6.4) | 21 (18.1) | 0.012 |
 DRIL, n (%) | 65 (28.8) | 24 (21.8) | 41 (35.3) | 0.026 |
 HF, n (%) | 99 (43.8) | 52 (47.3) | 47 (40.5) | 0.257 |
 IRC ≥ 600 µm, n (%) | 23 (10.2) | 9 (8.2) | 14 (12.1) | 0.399 |
 Disruption of ELM, n (%) | 61 (26.9) | 30 (27.3) | 31 (26.7) | 0.858 |
 Disruption of EZ, n (%) | 56 (24.8) | 18 (16.4) | 38 (32.8) | 0.003 |
 SRF, n (%) | 113 (50) | 59 (53.6) | 54 (46.6) | 0.316 |
 Foveal exudate, n (%) | 15 (6.6) | 6 (5.5) | 9 (7.8) | 0.507 |
Ocular characteristics at week 12 | ||||
 Mean (SD) VA, letter | 61.7 (17.8) | 63.6 (17.8) | 59.9 (17.7) | 0.172 |
 VA gain < 5 letters, n (%) | 80 (35.4) | 13 (11.8) | 67 (57.8) |  < 0.001 |
 CSFT reduction < 10%, n (%) | 78 (34.5) | 27 (24.6) | 51 (44.0) | 0.004 |
 DRIL, n (%) | 42 (18.6) | 13 (11.8) | 29 (25) | 0.012 |
 HF, n (%) | 63 (27.9) | 31 (28.2) | 32 (27.6) | 0.812 |
 IRC ≥ 600 µm, n (%) | 15 (6.6) | 4 (3.6) | 11 (9.5) | 0.046 |
 Disruption of ELM, n (%) | 43 (19) | 12 (10.9) | 31 (26.7) | 0.002 |
 Disruption of EZ, n (%) | 44 (19.5) | 12 (10.9) | 32 (27.6) | 0.002 |
 SRF, n (%) | 41 (18.1) | 24 (21.8) | 17 (14.7) | 0.256 |
 Foveal exudate, n (%) | 17 (7.5) | 6 (5.5) | 11 (9.5) | 0.428 |
During 12 months | ||||
 Mean (SD) number of injections | 7.3 (3.2) | 6.9 (3.2) | 7.5 (3.2) | 0.183 |
 Receiving additional macular laser photocoagulation, n (%) | 127 (56.2) | 59 (53.6) | 68 (58.6) | 0.494 |