Fig. 1

Amine oxidase copper-containing 3 (AOC3) is stored in intracellular vesicles and rapidly translocates to the luminal surface of endothelial cells during inflammation. Matrix metalloproteinases (MMPs) release a proportion of membrane-bound AOC3 resulting in a soluble, truncated form. Both membrane-bound and soluble AOC3 are enzymatically active. RBC red blood cell