Fig. 4
From: Large-cube 30° × 25° optical coherence tomography in diabetic macular edema
Evolution after intravitreal injections: a–d Left eye of a 65-year-old woman treated by intravitreal injection of Dexamethasone implant (Ozurdex®). Thickness map at baseline visit shows an diffuse DME that widely overflow outside the ETDRS grid in temporal and associated to another peripheral retinal edemas. Twelve weeks after the intravitreal injection, the main DME thickness and surface was reduced but the outside ETDRS part of DME remained thickened with the presence of microaneurysms. The others peripheral retinal oedemas disappeared or regressed. e–h Right eye of a 43-year-old woman treated by five consecutives by intravitreal injection of aflibercept (eyelea®). Thickness map at baseline visit an diffuse DME that slightly overflow outside the ETDRS grid in temporal but associated to two large peripheral retinal edemas in superior and inferior. Three weeks after the fifth injections, the main DME thickness dramatically reduced as well as the inferior peripheral retinal edema. However, the superior peripheral retinal edema remained thickened with the presence of a microaneurysm that could be the source of a DME relapse