Fig. 4
From: Aflibercept clearance through the drainage system in a rat model
Slides samples from different time points (TP) post intravitreal injections. From left to right are hematoxylin and eosin staining and immunostaining photos with magnification of ×20, 3-dimensional reconstruction and ×40 magnification. At TP 0 Aflibercept molecules are already seen in the anterior chamber angle (red signal). At TP 3, 6 the angle still stains positive for Aflibercept signal, with the signal highly concentrated in Schlemm’s canal at TP 6. In the two eyes at TP 24, only the first one presented still has a red fluorescence signal intensity, albeit decreased, and the other one is missing any signal. At TP 48 no red signal was detected, indicating complete clearance of Aflibercept from the eye. TM Trabecular meshwork, SC Schlemm’s canal, IVP Intrascleral venous plexus