Skip to main content

Table 3 Summary of previous studies using aflibercept for neovascular age-related macular degeneration (nvAMD) with a treat-and-extend (TAE) regime

From: Visual and anatomical outcomes associated with treat-and-extend administration of intravitreal aflibercept for neovascular age-related macular degeneration

Prospective studies
Study n Mean age Mean baseline VA (ETDRS letters) Visual change (ETDRS letters) Number of injections Treatment näive
Ohji et al. (ALTAIR) [19] 124a NA NA + 9.0 (1y) 7.2 Yes
123b NA NA + 8.4 (1y) 6.9
Haga et al. [6] 21 75.5 56.9 + 15.9 (1y) 7.5 NR
DeCroos et al. (ATLAS) [5] 35 81.3 58.9 + 7.2 (1y) 8.0 Yes
Hatz et al. [20] 33 81.0 66.8 − 0.6 (1y) NR No
Jørstad et al. [21] 50 NR 72.5g + 0.5(1y)g 9.2 No
Retrospective studies
Study n Mean age Mean baseline VA (ETDRS letters) Mean visual gain (ETDRS letters) Number of injections Treatment näive
Barthelmes et al. [7] 136 77.2 61.4 + 6.0 (2y) 13.6 Yes
Matsumoto et al. [8] 18c 75.7 53.5g + 9.5 (1y)g 7.7 Yes
44d 71.5 72.0g + 7.0 (1y)g 8.3 Yes
58e 72.4 71.5g + 8.0 (1y)g 7.7 Yes
5f 77.2 56.5g + 14.5 (1y)g 7.3 Yes
Matsumoto et al. [9] 60 75.1 69.5g + 9.0 (1y)g 13.8 (2y) Yes
Ohnaka et al. [10] 36 72.3 61.0g + 4 (1y)g 4.5 Yes
Yamamoto et al. [11] 67 NA 70.5g + 7.5 (1y)g 8.3 NA
Ito et al. [12] 61 NA NA + 6.5 (2y)g 13.6 Yes
Castro-Navarro et al. [13] 30 78.8 54.5g + 11.5 (1y)g 7.7 Yes
Unsal et al. [14] 38 74.5 39.1 + 15.9 (1y) 4.9 Yes
Ishibashi et al. [15] 39 75.5 63.9 + 6.5 (1y) 7.9 Mixed
Wakuta et al. [16] 16 78.3 65 0 (1y) 7.8 (1y) Mixed
Current Study 213 80.4 40.0 + 10.1 (1y) 7.4 Yes
  1. ETDRS Early Treatment Diabetic Retinopathy Study; VA visual acuity; NR not reported; NA not available; 1y one year; 2y two year
  2. a2-week adjustment of treat-and-extend regime
  3. b4-week adjustment of treat-and-extend regime
  4. cClassic (type I) choroidal neovascularization
  5. dOccult (type I) choroidal neovascularization
  6. ePCV polypoidal choroidal vasculopathy
  7. fRAP retinal angiomatous proliferation
  8. gValues reported in logarithm of the minimal angle (logMAR) and converted to approximate ETDRS letters for table