All eyes | Low-response group | High-response group | P-value | |
---|---|---|---|---|
Eyes, n (patients, n) | 59 (59) | 12 (12) | 47 (47) | |
Age, years (range) | 74.3 ± 7.9 (50–88) | 77.0 ± 5.9 (66–85) | 73.7 ± 8.2 (50–88) | 0.19 |
Sex (M/F), n | 41/18 | 7/5 | 34/13 | 0.48† |
Subtype (tAMD/PCV) | 30/29 | 6/6 | 24/23 | 1.00† |
Axial length, mm | 23.74 ± 0.91 | 23.61 ± 1.05 | 23.77 ± 0.89 | 0.59 |
LogMAR BCVA | ||||
Baseline | 0.28 ± 0.32 | 0.31 ± 0.37 | 0.27 ± 0.31 | 0.69 |
1 year after treatment | 0.18 ± 0.35 | 0.21 ± 0.24 | 0.17 ± 0.38 | 0.74 |
Change during 1 year | − 0.10 ± 0.27 | − 0.10 ± 0.27 | − 0.10 ± 0.27 | 0.96 |
Central retinal thickness at baseline, μm | 280.4 ± 113.6 | 306.8 ± 118.8 | 273.7 ± 112.5 | 0.37 |
Subfoveal choroidal thickness at baseline, μm | 231.8 ± 111.3 | 209.9 ± 90.4 | 237.4 ± 116.2 | 0.45 |
Genotype, n | ||||
ARMS2 A69S (GG/GT/TT) | 11/26/20a | 1/6/4b | 10/20/16c | 0.60‡ |
CFH I62V (AA/AG/GG) | 6/30/21d | 1/5/5e | 5/25/16f | 0.54‡ |
Vitreomacular interface scores at baseline | ||||
25 points | 19.5 ± 9.1 | 23.0 ± 4.3 | 18.6 ± 9.8 | 0.03* |
9 points | 6.5 ± 3.7 | 7.6 ± 3.0 | 6.3 ± 3.8 | 0.21 |
1 point | 0.7 ± 0.5 | 0.8 ± 0.5 | 0.6 ± 0.5 | 0.47 |
Qualitative vitreomacular interface status at baseline (VMA/VMT/complete PVD), n | 16/0/43 | 1/0/11 | 15/0/32 | 0.10‡ |
Qualitative vitreomacular interface status at baseline (VMA/complete PVD), n | 16/43 | 1/11 | 15/32 | 0.10† |