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Table 1 Comparison between the wet and dry groups

From: Influence of vitreomacular interface score on treatment outcomes of anti-VEGF therapy for neovascular age-related macular degeneration

 

All eyes

Low-response group

High-response group

P-value

Eyes, n (patients, n)

59 (59)

12 (12)

47 (47)

 

Age, years

(range)

74.3 ± 7.9

(50–88)

77.0 ± 5.9

(66–85)

73.7 ± 8.2

(50–88)

0.19

Sex (M/F), n

41/18

7/5

34/13

0.48

Subtype (tAMD/PCV)

30/29

6/6

24/23

1.00

Axial length, mm

23.74 ± 0.91

23.61 ± 1.05

23.77 ± 0.89

0.59

LogMAR BCVA

 Baseline

0.28 ± 0.32

0.31 ± 0.37

0.27 ± 0.31

0.69

 1 year after treatment

0.18 ± 0.35

0.21 ± 0.24

0.17 ± 0.38

0.74

 Change during 1 year

− 0.10 ± 0.27

− 0.10 ± 0.27

− 0.10 ± 0.27

0.96

Central retinal thickness at baseline, μm

280.4 ± 113.6

306.8 ± 118.8

273.7 ± 112.5

0.37

Subfoveal choroidal thickness at baseline, μm

231.8 ± 111.3

209.9 ± 90.4

237.4 ± 116.2

0.45

Genotype, n

 ARMS2 A69S (GG/GT/TT)

11/26/20a

1/6/4b

10/20/16c

0.60

 CFH I62V (AA/AG/GG)

6/30/21d

1/5/5e

5/25/16f

0.54

Vitreomacular interface scores at baseline

 25 points

19.5 ± 9.1

23.0 ± 4.3

18.6 ± 9.8

0.03*

 9 points

6.5 ± 3.7

7.6 ± 3.0

6.3 ± 3.8

0.21

 1 point

0.7 ± 0.5

0.8 ± 0.5

0.6 ± 0.5

0.47

Qualitative vitreomacular interface status at baseline (VMA/VMT/complete PVD), n

16/0/43

1/0/11

15/0/32

0.10

Qualitative vitreomacular interface status at baseline (VMA/complete PVD), n

16/43

1/11

15/32

0.10

  1. Data are presented as means ± standard deviations where applicable
  2. Low-response group: subretinal and/or intraretinal fluid observed on optical coherence tomography 1 year after the initial treatment
  3. High-response group: no subretinal or intraretinal fluid observed on optical coherence tomography 1 year after the initial treatment
  4. tAMD: typical age-related macular degeneration; PCV: polypoidal choroidal vasculopathy; logMAR BCVA: logarithm of the minimal angle of resolution best-corrected visual acuity; ARMS2: age-related maculopathy susceptibility protein 2; CFH: complement factor H; PVD: posterior vitreous detachment; VMA: vitreomacular adhesion without traction; VMT: vitreomacular traction
  5. In ARMS2 A69S, GG, GT, and TT represent non-risk-homo, hetero, and risk-homo, respectively
  6. In CFH I62V, AA, AG, and GG represent non-risk-homo, hetero, and risk-homo, respectively
  7. In measurements indicated by a, b, c, d, e, and f, data are missing for two, one, one, two, one, and one patients, respectively
  8. Chi-square test
  9. Chi-square trend test; the remaining: t-test
  10. *Statistically significant (P < 0.05)