Skip to main content

Table 3 Association analysis

From: Fluid dynamics between injections in incomplete anti-VEGF responders within neovascular age-related macular degeneration: a prospective observational study

Continuous variables

Mean ± SD

Association with relative response

Association with residual fluid amount

Age

80 ± 6.74

r − 0.08, p = 0.69

r < 0.01, p = 0.99

Number of switches

1 ± 1.12

r 0.12, p = 0.53

r 0.06, p = 0.82

Number of IVI

53.3 ± 24.4

r 0.08, p = 0.69

r − 0.14, p = 0.46

Choroid thickness

173.4 ± 120.9

r − 0.01, p = 0.98

r 0.17, p = 0.37

CRT at baseline

308.9 ± 77.6

r 0.13, p = 0.50

r − 0.15, p = 0.44

IRF volume at baseline

26.4 ± 45.8

r − 0.29, p = 0.13

r − 0.06, p = 0.77

SRF volume at baseline

129.8 ± 506.2

r 0.02, p = 0.91

r 0.76, p < 0.0001

PED volume at baseline

697.9 ± 863.4

r 0.07, p = 0.70

r 0.65, p = 0.0001

Polyps on OCT

0.34 ± 0.9

r − 0.1, p = 0.62

r 0.04, p = 0.83

Total baseline fluid (µl)

155.6 ± 211.4

r − 0.04, p = 0.84

r 0.73, p < 0.0001

Categorical variables

# present (%)

Association with relative response

Association with residual fluid amount

Gender (female)

22 (79)

p = 0.056

p = 0.39

Medication (R/A/B)

11/16/1

p = 0.58

p = 0.46

Fibrosis

5 (17.9)

p = 0.56

p = 0.52

RORA on OCT

14 (50)

p = 0.07

p = 0.069

Reticular pseudodrusen

11 (39.2)

p = 0.37

p = 0.72

Feeder vessel on ICGA

11 (39.2)

p = 0.55

p = 0.44

Pachydrusen

15 (53.6)

p = 0.76

p = 0.74

Basal laminar drusen

8 (28.9)

p = 0.15

p = 0.36

Presence of IRF at baseline

15 (53.6)

p = 0.14

p = 0.075

Presence of SRF at baseline

18 (64.3)

p = 0.47

p = 0.09

PCV on ICGA

2 (7.1)

p = 0.95

p = 0.001

Well-defined shape on OCT-A

18 (85.7)

p = 0.7

p = 0.92

Presence of numerous branching on OCT-A

4 (19)

p = 0.22

p = 0.59

Presence of anastomoses/loops on OCT-A

13 (61.9)

p = 0.36

p = 0.18

Presence of peripheral arcades on OCT-A

13 (61.9)

p = 0.94

p = 0.21

Presence of perilesional hyporeflective halo on OCT-A

11 (52.4)

p = 0.54

p = 0.5

  1. Association analysis between variables and relative response/residual fluid in terms of the sum of intra- and subretinal fluid volume at its strongest response time point. Pearson correlation test was used for continuous variables and ANOVA for categorical variables
  2. IVI intravitreal injection, CRT central retinal thickness, IRF intraretinal fluid, SRF subretinal fluid, PED pigment epithelium detachment, OCT optical coherence tomography, R ranibizumab, A aflibercept, B bevacizumab, RORA retinal pigment epithelium and outer retinal atrophy, ICGA indocyanine green angiography, PCV polypoidal choroidal vasculopathy, OCT-A OCT-angiography