Fig. 2

Histopathological examination of the lens capsule of the three patients. Case 1: A Low magnification (PAS [Periodic acid Schiff] staining) shows areas of fibrosis of anterior and posterior lens capsule (black arsterisks), as well as localized inflammatory infiltration with formation of microabscess (red arrows). B, C On Grocott methenamine silver staining, multiple fungal structures are seen sequestered between the anterior and posterior lens capsule on higher magnification. Case 2: D Low magnification image (hematoxylin–eosin [HE] staining) displays dense inflammatory cell infiltration (red arrows), intermingled with foci of fibrosis (black asterisks). E, F PAS E and Grocott F staining reveal numerous septate fungal hyphae within the capsular bag, sequestered between anterior and posterior lens capsule. Case 3: G Low magnification (HE staining) shows focus of inflammatory infiltration (red arrow) and area of fibrosis (black asterisk). H On high magnification, a round PAS positive structure consistent with fungal element is disclosed (green arrowhead); vitreal culture eventually grew Acremonium sp