Fig. 1

Patient with chronic DME and recently unsustained anti-VEGF response. A SD-OCT monthly follow-up of prn-IVA ("pro re nata" intravitreal aflibercept) therapy with associated SWiT laser therapy on week 24 after two consecutive unresponsive IVA injections. Anatomical SD-OCT image showing hyporreflective intraretinal cysts with mean CST (µm) and BCVA (Snellen) of approximately 743 and 20/200, respectively, at baseline. B Macular thickness map (dashed red rectangle) correlated with cystic hyper-reflectance edema on near-IR (dashed cyan square). C Twenty-fourth week of follow-up showing SD-OCT section [smaller dashed green rectangle with representative laser targets spots from green (SPD) and purple (EpM) asterisks] and the mean CST of 818 µm on the thickness map (bigger dashed green rectangle) and near-IR revealing hyper-reflectance dots (dashed cyan square) from recent SWiT laser therapy (SPD, green stars and EpM, light purple stars). D Forty-week follow-up revealing SD-OCT section (smaller dashed yellow rectangle) and the mean CST of 217 µm on the thickness map (bigger dashed yellow rectangle) after 8 weeks of combined IVA and SWiT laser therapy. Absent cystic hyper-reflectance edema showing ellipsoid band irregularities corroborating hyper-reflectance dots on near-IR (dashed cyan square). Visual acuity (BCVA of 20/80) stability since the 32nd week of follow-up