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Fig. 5 | International Journal of Retina and Vitreous

Fig. 5

From: Pascal short-pulse plus subthreshold endpoint management laser therapy for diabetic macular edema: the “sandwich technique”

Fig. 5

Patient with chronic DME and recently unsustained anti-VEGF response. A SD-OCT 20-week monthly follow-up of prn-IVA therapy and associated SWiT laser therapy on week 16 after two consecutive unresponsive IVA injections. Anatomical SD-OCT image with mean CST (µm) of 304 and visual BCVA (Snellen) of approximately 20/125 at baseline. B Baseline intermediate phase of fluorescein angiography (dashed orange square) revealing hyperfluorescent microaneurysms (red arrowheads) correlated with thickened edema (dashed cyan square) on the thickness-map (white-lined square). C Intermediate phase of fluorescein angiography (dashed yellow square) after a 20-week follow-up showing hypofluorescent density spots (green arrowheads) related to SPD laser shots and subthreshold anatomical representative EpM targets (light purple stars). Absence of edema (dashed cyan square) on the corresponding thickness map area (white-lined square) and undetectable fluorescein angiography of inactive microaneurysms. After the 20-week follow-up, visual improvement (Snellen BCVA of 20/60) correlated with the anatomical CST decrease (255 µm) on the SD-OCT image after 4 weeks of SWiT therapy

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