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Table 2 Clinical and laboratory variables associated with SCR and PSCR

From: Risk factors associated with sickle cell retinopathy: findings from the Cooperative Study of Sickle Cell Disease

Characteristic

Whole cohort

SCR

PSCR

n = 1904

Yes (n = 953)

n (%)

No (n = 951)

n (%)

P-valuea

Yes (n = 423)

n (%)

No (n = 1481)

n (%)

P-valuea

Previous history of

       

 Seizure

150 (7.9%)

68 (7.2%)

82 (8.6%)

0.234

30 (7.1%)

120 (8.1%)

0.502

 CVA

134 (7.0%)

59 (6.2%)

75 (7.9%)

0.152

24 (5.7%)

110 (7.4%)

0.217

 Aseptic necrosis

334 (17.5

208 (21.9%)

126 (13.2%)

 < 0.001

114 (27.0%)

220 (14.9%)

 < 0.001

 Hematuria

250 (13.1%)

155 (16.7%)

95 (10.5%)

 < 0.001

76 (18.4%)

174 (12.2%)

0.001

 Nephrotic syndrome

68 (3.6%)

37 (4.0%)

31 (3.4%)

0.528

15 (3.6%)

53 (3.7%)

0.921

 Hearing loss

116 (6.1%)

62 (6.6%)

54 (5.9%)

0.534

29 (7.0%)

87 (6.1%)

0.516

 Heart disease

246 (12.9%)

133 (14.3%)

113 (12.4%)

0.239

62 (14.9%)

184 (12.9%)

0.292

 Hand foot syndrome

617 (32.4%)

296 (35.3%)

321 (37.5%)

0.342

110 (29.9%)

507 (38.2%)

 < 0.001

 Spleen infarction

163 (8.6%)

68 (7.5%)

95 (10.8%)

0.016

38 (9.4%)

125 (9.1%)

0.836

 Pneumonia

1045 (54.9%)

551 (59.7%)

494 (54.4%)

0.022

254 (61.5%)

791 (55.8%)

0.039

 Lung infarction

86 (4.5%)

50 (5.5%)

36 (4.0%)

0.148

26 (6.4%)

60 (4.3%)

0.076

 Leg ulcers

235 (12.3%)

147 (15.7%)

88 (9.6%)

 < 0.001

77 (18.5%)

158 (11.0%)

 < 0.001

 Painful crisis

975 (51.2%)

518 (55.0%)

457 (48.4%)

0.004

237 (56.8%)

738 (50.2%)

0.017

 Blood transfusion

1140 (59.9%)

617 (66.0%)

523 (57.3%)

 < 0.001

274 (66.0%)

866 (60.4%)

0.039

Laboratory data

       

 Hemoglobin (g/dl)b

9.0 (8.0–10.6)

9.1 (8.0–10.8)

8.9 (8.0–10.2)

0.008

10.0 (8.4–11.5)

8.8 (7.9–10.1)

 < 0.001

 WBC (109/L)b

10.8 (8.7–13.0)

10.7 (8.7–12.9)

10.9 (8.7–13.1

0.296

10.5 (8.1–12.7)

10.9 (8.9–13.1)

0.002

 Platelets (109/L)b

392.0 (300.0–480.2)

382.0 (296.0–465.3)

402.6 (302.9–494.7)

0.008

354.0 (266.7–439.5)

405.5 (310.8–487.5)

 < 0.001

 Reticulocytes (%)b

9.7 (5.5–13.8)

9.4 (5.2–13.4)

10.0 (5.9–14.1)

0.020

7.5 (4.3–11.6)

10.2 (6.2–14.2)

 < 0.001

 HbF (%)b

3.8 (2.0–7.6)

3.3 (1.7–6.0)

4.7 (2.3–9.0)

 < 0.001

2.6 (1.2–4.5)

4.4 (2.2–8.5)

 < 0.001

  1. SCR sickle cell retinopathy, PSCR proliferative sickle cell retinopathy, CVA cerebrovascular accident, WBC white blood cells, HbF hemoglobin F
  2. Significant associations are marked in bold (p < 0.05)
  3. aP-values determined using chi-square test for categorical variables and Mann–Whitney U test for continuous variables (age at entry)
  4. bMedian (interquartile range)
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International Journal of Retina and Vitreous

ISSN: 2056-9920

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