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Table 3 OCT characteristics at baseline for morphological responders and non-responders to one intravitreal bevacizumab injection

From: Short-term outcomes in patients with center-involving diabetic macular edema after a single dose of intravitreal bevacizumab

 

Responders

(n = 22)

Non-responders

(n = 30)

p-value

Vitreous status, n (%)

   

 Completely attached

1 (4.8)

1 (3.6)

0.8

 VMA

1 (4.8)

8 (28.7)

0.03

 VMT

1 (4.8)

2 (7)

0.73

 Completely detached

18 (85.6)

17 (60.7)

0.055

ERM, n (%)

14 (63.6)

13 (43.3)

0.15

 Thick ERM

1 (7.1)

3 (23.1)

0.47

 Thin ERM

13 (92.9)

10 (76.9)

0.065

Intraretinal cysts, n (%)

   

 Ganglion cell layer

5 (22.7)

4 (13.3)

0.38

 Inner nuclear layer

21 (95.5)

22 (73.3)

0.037

 Outer plexiform layer

2 (9.1)

4 (13.3)

0.64

 Outer nuclear layer

22 (100)

25 (83.3)

0.07

 Elongated shape

15 (68.2)

17 (56.7)

0.4

 Polygonal shape

18 (81.8)

23 (76.7)

0.65

 Round shape

12 (54.5)

10 (33.3)

0.13

 Hyporeflective

8 (36.4)

6 (20)

0.19

 Isoreflective

0 (0)

2 (6)

0.22

 Hyper-reflective

0 (0)

0 (0)

 

 Mixed reflectivity

14 (63.6)

18 (60)

0.79

Hyper-reflective foci, n (%)

17 (77.3)

23 (76.7)

0.96

 Intracystic

13 (59.1)

21 (70)

0.71

 Non-cystic

16 (72.7)

21 (70)

0.83

Exudates, n (%)

   

 Absent

2 (9.1)

2 (6.7)

0.75

 < 5 present

18 (81.8)

21 (70)

0.33

 > 5 present

2 (9.1)

7 (23.3)

0.18

DRIL, n (%)

   

 No

12 (54.5)

20 (66.7)

0.38

 Yes

10 (45.5)

10 (33.3)

 

ELM disruption, n (%)

   

 No

19 (86.4)

26 (86.7)

0.98

 Yes

3 (13.6)

4 (13.3)

 

EZ disruption, n (%)

   

 No

14 (63.6)

22 (73.3)

0.45

 Yes

8 (36.4)

8 (26.7)

 

Subretinal fluid, n (%)

   

 No

12 (54.5)

26 (86.7)

0.01

 Yes

10 (45.5)

4 (13.3)

 

 Hyporeflective

7 (70)

3 (75)

0.85

 Isoreflective

0 (0)

0 (0)

 

 Hyper-reflective

0 (0)

0 (0)

 

 Mixed reflectivity

3 (30)

1 (25)

0.85

  1. OCT: Optical coherence tomography; VMA: Vitreomacular adhesion; VMT: Vitreomacular traction; ERM: Epiretinal membrane; ELM: External limiting membrane; EZ: Ellipsoid zone; DRIL: Disorganization of retinal inner layers
  2. Data are presented as number (%) with p-values derived from respective Chi-Square (χ2) analyses
  3. Statistical significance was set at p < 0.05.