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Table 1 Studies Included in the Analysis

From: Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group

First author, year

Study type

no. eyes

Mean age (years)

MLD (µm)

Pre-VA (logMAR)

Post-VA (logMAR)

Surgical technique

Closure

Moysidis et al. [12]

Multicenter, retrospective, global consortium

130

63 (± 6.3)

840

1.37 (± 0.12)

1.05 (± 0.09)

ART

115/130 (88.4%)

Meyer et al. [13]

Multicenter, retrospective, case series

41

NA

1,276

1.22 (± 0.45)

0.72 (± 0.31)

Macular hydro

35/41 (85.4%)

Michalewska et al. [14, 15]

Prospective, randomized clinical trial [46]

Prospective comparative interventional [47]

157

67.1 (± 10.2)

594 (± 147.0)

0.99 (± 0.35)

0.65 (± 0.40)

ILM flap

154/157 (98.1%)

Giansanti et al. [16]

Retrospective, consecutive, nonrandomized

8

74 (± 4.8)

436 (± 46.9)

0.81 (± 0.16)

0.66 (± 0.09)

ILM flap

8/8 (100%)

Steel et al. [7]

Multicenter, retrospective

636

69.5 (± 7.5)

525 (± 104)

1.04 (± 0.42)

0.55 (± 0.34)

ILM peel

47/637 (92.6%)

Kumar and Yadav [17]

Retrospective, case series

25

56.8 (± 14.9)

501

(± 162)

1.04 (± 0.29)

0.60 (± 0.29)

ILM peel

25/25 (100%)

Kikushima et al. [18]

Single-center, prospective interventional case series

20

63.5 (± 12.6)

373 (± 139)

0.515 (± 0.28)

NA

ILM peel

20/20 (100%)

Frisina et al. [19]

Prospective, interventional case series

10

NA

230 (± 117)

1.06 (± 0.08)

0.56 (± 0.22)

Macular hydro

9/10 (90%)

Primavera et al. [20]

Single-center, case series

5

67.4 (± 5.9)

666 (± 167)

1.08 (± 0.37)

0.52 (± 0.15)

ILM flap

5/5 (100%)

Wong et al. [21]

Retrospective, interventional case series

16

72.3 (± 8.9)

739 (± 62)

1.36 (± 0.45)

0.9 (± 0.24)

Macular hydro

14/16 (87.5%)

Liu et al. [22]

Case report

1

68

NA

1.4

0.4

ART

1/1 (100%)

Rizzo et al. [23]

Prospective, interventional case series

8

69.5 (± 14.1)

578 (± 170.6)

1.49 (± 0.50)

0.64 (± 0.25)

hAM

8/8 (100%)

Grewal and Mahmoud [24]

Case report

1

50

1100

1

0.6

ART

1/1 (100%)

Caporossi et al. [25]

Prospective, consecutive, interventional

16

68.3 (± 11.4)

716 (± 355)

0.94 (± 0.24)

0.67 (± 0.27)

hAM

15/16 (93.75%)

Fung et al. [26]

Retrospective, interventional, single center

8

67.5 (± 6.6)

821 (± 361)

1.04 (± 0.19)

0.69 (± 0.21)

ILM flap

7/8 (87.5%)

Chang et al. [27]

Retrospective, case series, single center

10

64.9 (± 11.5)

1404 (± 562.9)

1.72 (± 0.58)

0.89 (± 0.55)

ART

9/10 (90%)

Chen [28]

Retrospective case series

17

63 (± 11.6)

500

1.22 (± 0.59)

0.64 (± 0.4)

ILM flap

16/16 (100%)

Dai et al. [29]

Prospective, interventional case series

13

55.3 (± 19.6)

814 (± 255)

1.15 (± 0.21)

0.99 (± 0.17)

ILM flap

13/13 (100%)

de Novelli et al. [30]

Prospective, interventional case series

10

60.8 (± 14.3)

669 (± 170.0)

1.30 (± 0.47)

0.99 (± 0.33)

ILM flap

10/10 (100%)

Tanaka et al. [31]

Retrospective, case series single center

7

71.4 (± 8.6)

661 (± 103.7)

1.23 (± 0.21)

0.84 (± 0.49)

ART

7/7 (100%)

Kang et al.. [32]

Retrospective case series

29

63.5 (± 8.6)

537 (± 214.1)

0.92 (± 0.33)

0.55 (± 0.28)

ILM peel

19/29 (65.5%)

Chen et al. [33]

Prospective, interventional, single center

8

65.(± 9.0)

628 (± 172.4)

1.28 (± 0.39)

0.63 (± 0.22)

ILM flap

8/8 (100%)

Kusuhara et al. [34]

Prospective interventional case series

25

64.9 (± 6.3)

315 (± 141.1)

0.90 (± 0.31)

0.37 (± 0.37)

ILM peel

25/25 (100%)

Mahalingam et al. [35]

Prospective interventional case series

5

67 (± 5.4)

811 (± 106.2)

1.26 (± 0.30)

1.10 (± 0.23)

ILM flap

5/5 (100%)

Shakya et al. [36]

Case series

10

NA

1039 (± 291.2)

1.29 (± 0.25)

0.93 (± 0.14)

ILM flap

10/10 (100%)

Wong [37]

Case series

3

81 (± 9.0)

717 (± 23.9)

1.60 (± 0.69)

0.87 (± 0.12)

Macular hydro

3/3 (100%)

Wu et al. [38]

Retrospective, consecutive, interventional case series

6

59 (± 9.9)

538 (± 202.6)

1.47 (± 0.31)

1.08 (± 0.53)

ART

4/6 (66.7%)

Ferreira et al. [39]

Retrospective chart review

19

66 (± 15.0)

856 (± 459.3)

1.1 (± 0.44)

1.1 (± 0.72)

hAM

19/19 (100%)

Caporossi et al. [40]

Prospective, interventional, comparative

20

68 (± 12.3)

789 (± 155.7)

1.1 (± 0.48)

0.54 (± 0.14)

hAM

20/20 (100%)

Meyer et al. [41]

Case report

1

83

1444

3

1

Macular hydro

1/1 (100%)

Total

 

1265

      
  1. NA not applicable, ILM internal limiting membrane, macular hydro macular hydrodissection, VA preoperative visual acuity (logMAR), post-VA postoperative visual acuity (logMAR), logMAR logarithm of the minimum angle of resolution, hAM human amniotic membrane, ART autologous retinal transplantation