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Table 1 Age and visual acuity demographics for healthy control eyes and various retinal disease states

From: Quantitative cone contrast threshold testing in patients with differing pathophysiological mechanisms causing retinal diseases

 

Group

# Patients, # eyes

Age (mean ± std dev (range))

p-value

Visual Acuity in logMAR (mean ± std dev (range))

p-value

Pseudophakic (n (%))

p-value

MS

Healthy controls

123, 200

48.5 ± 21.9 (19–92)

 

− 0.03 ± 0.14 (− 0.88 to 0.13)

 

52 (26%)

 

No History of Optic Neuritis

14, 22

51.3 ± 11.9 (29–70)

0.36

− 0.04 ± 0.10 (− 0.30 to 0.00)

0.22

2 (9%)

0.17

 + History of Optic Neuritis

6, 9

44.1 ± 11.7 (30–61)

0.31

− 0.09 ± 0.16 (− 0.63 to 0.00)

0.97

0 (0%)

0.14

AMD

Healthy controls (≥ 64 years)

54, 73

72.5 ± 6.0 (64–92)

 

− 0.09 ± 0.17 (− 0.88 to 0.13)

 

45 (62%)

 

Early

14, 23

75.6 ± 8.6 (64–94)

.12

− 0.12 ± 0.12 (− 0.40 to 0.00)

0.97

13 (57%)

0.85

Intermediate

24, 37

79.1 ± 7.6 (67–93)

 < .01*

− 0.17 ± 0.16 (− 0.48 to 0.00)

0.19

24 (65%)

0.90

Advanced

6, 7

82.9 ± 8.7 (69–90)

0.02*

− 0.31 ± 0.20 (− 0.60 to 0.10)

0.08

4 (57%)

0.99

 

Neovascular

7, 10

83.5 ± 6.3 (74–93)

 < .01*

− 0.30 ± 0.14 (− 0.48 to 0.10)

 < .01*

8 (80%)

0.43

ERM

Healthy controls

(≥ 50 years)

74, 103

72.3 ± 10.4 (50–94)

 

− 0.18 ± 0.15 (− 0.54 to 0.00)

 

52 (51%)

 

Stage 1

26, 30

74.7 ± 10.8 (56–94)

 < .01*

− 0.14 ± 0.14 (− 0.50 to 0.00)

0.33

20 (67%)

0.17

Stage 2

17, 20

71.0 ± 10.2 (50–87)

0.24

− 0.19 ± 0.17 (− 0.54 to 0.00)

0.08

13 (65%)

0.34

Stage 3

6, 7

66.0 ± 6.5 (56–74)

0.45

− 0.28 ± 0.13 (− 0.54 to 0.18)

0.05*

4 (57%)

0.99

RVO

Total

11, 11

68.0 ± 10.7 (51–81)

NA

− 0.26 ± 0.16 (− 0.48 to 0.00)

NA

5 (46%)

NA

  1. aThe healthy control group includes healthy fellow eyes to eyes with unilateral disease
  2. bPatients with eyes categorized in 2 different groups were included in the patient number for both groups
  3. *Asterisks denote t-test and chi-square differences that are statistically significant at p < 0.05