Table 2 Mean MARINA study vision levels (years 1–2), HORIZON extension trial (years 3–4), then last observation carried forward to year 12 in the 0.5 mg treatment cohort, with a meta-analysis control cohort from years 3–12

Baseline

20/80 − 1

20/80 − 1

6 months

20/100 − 2

20/63

12 months

20/126

20/63 + 1

18 months

20/160 + 2

20/63 + 1

24 months

20/160 − 1.5

20/63 + 1

3 years

20/250

20/63 + 1

4 years

20/320

20/80 + 2

5 years

20/400

20/80 + 1

6 years

20/500 + 2

20/80 + 1

7 years

20/500

20/80 + 1

8 years

20/640 + 2

20/80 + 1

9–12 years

20/640

20/80 + 1