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Table 6 A review of previous studies using radiotherapy (SRT, EBRT, GKR) for uveal metastases

From: Gamma knife radiosurgery for the treatment of uveal melanoma and uveal metastases

Study Eyes Radiation dose (Gy) Follow-up (months) Visual acuity Complications Survival (%)
Before After Radiation retinopathy (%) Radiation neuropathy (%) Neovascular glaucoma (%)
Bellman et al. [8] Single-dose or fractionated SRT 10 12–20 Gy in a single dose or 30 Gy over 10 days to 50% isodose 6.5 (median) 20/26–20/320 20/26-LP NR    NR
Bajcsay et al. [19] EBRT 24 46 Gy (maximum average dose) 24 (mean) 0.1–0.7 Improvement of two lines 3.5 0 0 4.2
Wiegel et al. [18] Radiotherapy 65 40 Gy in 20 fractions (50% isodose) 5.8 (median) 20/32 Visual acuity increased for two or more lines in 36%, stabilized in 50%, and decreased in 14% 1.5 1.5   18
Current study GKR 7 20.0 ± 2.34 (50% isodose) 6.03 ± 6.32 (median) 20/25–20/600 20/25-HM 0 0 14.3 14.3