Table 6 A review of previous studies using radiotherapy (SRT, EBRT, GKR) for uveal metastases
From: Gamma knife radiosurgery for the treatment of uveal melanoma and uveal metastases
Study | Eyes | Radiation dose (Gy) | Follow-up (months) | Visual acuity | Complications | Survival (%) | |||
|---|---|---|---|---|---|---|---|---|---|
Before | After | Radiation retinopathy (%) | Radiation neuropathy (%) | Neovascular glaucoma (%) | |||||
Bellman et al. [8] Single-dose or fractionated SRT | 10 | 12–20 Gy in a single dose or 30 Gy over 10 days to 50% isodose | 6.5 (median) | 20/26–20/320 | 20/26-LP | NR | NR | ||
Bajcsay et al. [19] EBRT | 24 | 46 Gy (maximum average dose) | 24 (mean) | 0.1–0.7 | Improvement of two lines | 3.5 | 0 | 0 | 4.2 |
Wiegel et al. [18] Radiotherapy | 65 | 40 Gy in 20 fractions (50% isodose) | 5.8 (median) | 20/32 | Visual acuity increased for two or more lines in 36%, stabilized in 50%, and decreased in 14% | 1.5 | 1.5 | 18 | |
Current study GKR | 7 | 20.0 ± 2.34 (50% isodose) | 6.03 ± 6.32 (median) | 20/25–20/600 | 20/25-HM | 0 | 0 | 14.3 | 14.3 |