Fig. 10

Example images of ischemic index calculation. Left eye of a 27-year-old man with sickle cell SC genotype and Goldberg stage 3 (proliferative) sickle cell retinopathy. Top row, Montage ultra wide-field fluorescein angiography (left). The area of non perfusion is shaded in white on the mask (right), whereas the total perfused area is shown in gray. Middle row, Superficial capillary plexus OCT angiography (left), vessel density map (middle), and vessel density values (right). Bottom row, Deep capillary plexus optical coherence angiography (left), vessel density map (middle), and vessel density values (right). OCTA loss of macular flow was significantly correlated with ischemic index in sickle cell retinopathy patients. Flow loss is commonly noted in both the superficial and deep capillary plexuses, and often more commonly observed in the deep capillary plexus (arrow). RPE = retinal pigment epithelium. Reprinted with permission from Han IC, Linz MO, Liu TYA, Zhang AY, Tian J, Scott AW. Correlation of ultra-widefield fluorescein angiography and OCT angiography in sickle cell retinopathy. Ophthalmology Retina. 2018;2(6):599-605