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Table 3 Absolute and percent change from baseline in excess CST to Weeks 2, 4, and 8 (FAS)

From: Primary outcomes of the VIDI study: phase 2, double-masked, randomized, active-controlled study of ASP8232 for diabetic macular edema

 

ASP8232

ASP8232/ranibizumab

Ranibizumab

Baseline

n

32

32

31

Mean (SD)

215.8 (117.9)

191.8 (103.9)

181.6 (105.5)

Week 2

n

31

32

30

Mean (SD)

230.9 (134.3)

62.3 (109.1)

71.5 (85.3)

%CFB

16.3 (39.4)

− 69.3 (55.4)

− 57.6 (51.9)

Week 4

n

32

32

31

Mean (SD)

223.1 (130.6)

76.7 (115.0)

88.8 (109.0)

%CFB

11.6 (44.1)

− 56 (57.0)

− 50.2 (64.4)

Week 8

n

32

32

29

Mean (SD)

224.5 (110.1)

64.9 (114.8)

69.4 (118.8)

%CFB

17.7 (57.1)

− 55.1 (77.3)

− 66.0 (57.0)

  1. CST central subfield thickness, FAS full analysis set, SD standard deviation