Fig. 3

Cavitations of the foveal pit in the lower foveal walls as a characteristic of degenerative lamellar macular holes in 6 eyes of 6 patients. The months after the first visit (0) are indicated above or left of the images. Yellow and pink arrowheads indicate lamellar hole-associated epiretinal proliferation (LHEP). The arrows indicate tissue bands of medium reflectivity which connect glial cells in the center of the foveola with LHEP at the inner surface of the foveal walls. a–d Radial scans of four cases of a degenerative lamellar macular hole. The orientations of the SD-OCT scans are shown at the left side. The blue arrowhead in a indicates the adherence of a membrane to the temporal parafovea. e Development of a degenerative lamellar hole. f Development of a full-thickness macular hole from a lamellar hole. Scale bars, 200 µm. ELM, external limiting membrane; EZ, ellipsoid zone; GCL, ganglion cell layer; HFL, Henle fiber layer; INL, inner nuclear layer; IPL, inner plexiform layer; IZ, interdigitation zone; NFL, nerve fiber layer; ONL, outer nuclear layer; OPL, outer plexiform layer; RPE, retinal pigment epithelium