Fig. 2

NIR series of newly developing NVE. Baseline NIR a and fluorescein angiography b respectively showing no reflective changes and no leakage. At 6 months follow-up, observe a new hyporeflective change arising from a secondary inferior branch venule (c, box). The patient was then lost to follow-up and at the returning visit 4 years from baseline, 2 vascular loops and a fully developed neovascular frond (box) were documented in NIR d as hyporeflective irregular vessels. Optical coherence tomography e at the level of the arrow in d shows the neovascular tissue (✱) growing along the posterior hyaloid outer surface without invading the premacular bursa (▲). Despite panretinal photocoagulation, f shows progression of the NVE with more hyporeflective fronds and fluorescein leakage (g)