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Table 1 Diagnostic criteria for POEMS syndrome: [1]

From: Peripheral retinal leakage in POEMS syndrome

Requires two mandatory criteria PLUS ≥ 1 major AND ≥ 1 minor criteria
Mandatory criteria
  Polyneuropathy (typically demyelinating)
  Monoclonal plasma cell-proliferative disorder (almost always λ)
Major criteria
  Castleman disease(lymphoproliferative disorder)
  Sclerotic bone lesions
  Vascular endothelial growth factor (VEGF) elevation
Minor criteria
  Organomegaly (splenomegaly, hepatomegaly, or lymphadenopathy)
  Extravascular volume overload (edema, pleural effusion, or ascites)
  Endocrinopathy (adrenal, pituitary, gonadal, parathyroid, thyroid and pancreatic)
  Skin changes (hyperpigmentation, hypertrichosis, glomeruloid hemangiomata, plethora, acrocyanosis, flushing, and white nails)