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Table 2 OCT features of Main DME compared to those of peripheral retinal edemas

From: Large-cube 30° × 25° optical coherence tomography in diabetic macular edema

Features

Main DME

Peripheral retinal edemas

P value (coefficient of association)

Hard exudates, No (%)

κ = 0.92

κ = 0.93

 < 0.001 (0.38)

Absent

45 (13.3%)

17 (5.6%)

Present

294 (86.7%)

288 (94.4%)

Microaneurysms, No (%)

κ = 0.87

κ = 0.86

 < 0.001 (0.24)

Absent

10 (2.9%)

6 (2%)

Present

329 (97.1%)

299 (98%)

Cyst Size, No (%)

κ = 0.88

κ = 0.89

0.027 (0.18)

Absent

5 (1.5%)

0

Small

94(27.7%)

225 (73.8%)

Small + Intermediate

117(34.5%)

69 (22.6%)

Small + Intermediate + Large

123(36.3%)

11 (3.6%)

Cyst location, No (%)

κ = 0.89

κ = 0.90

0.42 (0.19)

Absent

5 (1.5%)

0

Outer retina

109 (32.1%)

232 (76.1%)

Outer + intermediate retina

136 (40.1%)

70 (23%)

Outer + intermediate + inner retina

66 (19.5

2 (0.6%)

Intermediate retina

17 (5.0%)

1 (0.3%)

Intermediate + inner retina

6 (1.8%)

0

Location of peak, No (%)

κ = 0.92

κ = 0.93

 

Central

30 (8.8%)

  

Inferior Inner

32 (9.4%)

  

Nasal Inner

42 (12.4%)

  

Superior Inner

41 (12.1%)

  

Temporal Inner

76 (22.4%)

  

Inferior Outer

18 (5.3%)

60 (19.6%)

0.397 (0.17)

Nasal Outer

13 (3.8%)

28 (9.2%)

Superior Outer

28 (8.3%)

82 (27.2%)

Temporal Outer

59 (17.4%)

135 (44%)

Highest retinal thickness (µm), Mean ± SD

ICC = 0.95

409.35 ± 91.27

ICC = 0.94

321.71 µm ± 71.84

 < 0.001 (0.42)

  1. DME diabetic macular edema, ETDRS early treatment diabetic retinopathy study, CMT central macular thickness, SD standard deviation
  2. In bold italics: statistically significative (after Bonferroni adjustment)
  3. κ: Chohen’s Kappa Coefficient for inter-Observers agreement; ICC: intraclass coefficient for inter-Observers agreement
  4. Chi-Square test (Cramer’s V coefficient)
  5. Pearson Correlation (Pearson’s r Coefficient)