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Table 2 OCT features of Main DME compared to those of peripheral retinal edemas

From: Large-cube 30° × 25° optical coherence tomography in diabetic macular edema

Features Main DME Peripheral retinal edemas P value (coefficient of association)
Hard exudates, No (%) κ = 0.92 κ = 0.93  < 0.001 (0.38)
Absent 45 (13.3%) 17 (5.6%)
Present 294 (86.7%) 288 (94.4%)
Microaneurysms, No (%) κ = 0.87 κ = 0.86  < 0.001 (0.24)
Absent 10 (2.9%) 6 (2%)
Present 329 (97.1%) 299 (98%)
Cyst Size, No (%) κ = 0.88 κ = 0.89 0.027 (0.18)
Absent 5 (1.5%) 0
Small 94(27.7%) 225 (73.8%)
Small + Intermediate 117(34.5%) 69 (22.6%)
Small + Intermediate + Large 123(36.3%) 11 (3.6%)
Cyst location, No (%) κ = 0.89 κ = 0.90 0.42 (0.19)
Absent 5 (1.5%) 0
Outer retina 109 (32.1%) 232 (76.1%)
Outer + intermediate retina 136 (40.1%) 70 (23%)
Outer + intermediate + inner retina 66 (19.5 2 (0.6%)
Intermediate retina 17 (5.0%) 1 (0.3%)
Intermediate + inner retina 6 (1.8%) 0
Location of peak, No (%) κ = 0.92 κ = 0.93  
Central 30 (8.8%)   
Inferior Inner 32 (9.4%)   
Nasal Inner 42 (12.4%)   
Superior Inner 41 (12.1%)   
Temporal Inner 76 (22.4%)   
Inferior Outer 18 (5.3%) 60 (19.6%) 0.397 (0.17)
Nasal Outer 13 (3.8%) 28 (9.2%)
Superior Outer 28 (8.3%) 82 (27.2%)
Temporal Outer 59 (17.4%) 135 (44%)
Highest retinal thickness (µm), Mean ± SD ICC = 0.95
409.35 ± 91.27
ICC = 0.94
321.71 µm ± 71.84
 < 0.001 (0.42)
  1. DME diabetic macular edema, ETDRS early treatment diabetic retinopathy study, CMT central macular thickness, SD standard deviation
  2. In bold italics: statistically significative (after Bonferroni adjustment)
  3. κ: Chohen’s Kappa Coefficient for inter-Observers agreement; ICC: intraclass coefficient for inter-Observers agreement
  4. Chi-Square test (Cramer’s V coefficient)
  5. Pearson Correlation (Pearson’s r Coefficient)