Table 1 Descriptive data
Group | Treatment | Photoreceptor cells density (mean ± SD) | p-value | Ganglion cells density (mean ± SD) | p-value | Caspase-3 expression on Photoreceptor cells (n) | p-value | Caspase-3 expression on Ganglion cells (mean ± SD) | p-value | Caspase-7 expression on Photoreceptor cells (n) | p-value | Caspase-7 expression on Ganglion cells (mean ± SD) | p-value | Blood glucose level (mean ± SD) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Negative control (Wild type) | 843 ± 32 | 0.002a | 26 ± 1 | 0.010a | High: 0 Low: 2 Neg: 3 | 0.016b | 16.80 ± 3.701 | 0.010a | High: 0 Low: 3 Neg: 2 | 0.069b | 18.60 ± 1.94 | 0.010a | 82 ± 2 |
2 | Alloxan induction without treatment | 565 ± 95 | 19 ± 3 | High: 4 Low: 1 Neg: 0 | 76.20 ± 14.97 | High: 2 Low: 3 Neg: 0 | 77.20 ± 10.82 | 276 ± 15 | ||||||
3 | Retinol for 7 days | 536 ± 138 | 18 ± 5 | High: 2 Low: 3 Neg: 0 | 33.80 ± 5.16 | High: 2 Low: 3 Neg: 0 | 44.80 ± 25.78 | 349 ± 63 | ||||||
4 | α-tocopherol for 7 days | 701 ± 88 | 25 ± 5 | High: 1 Low: 4 Neg: 0 | 32.80 ± 2.28 | High: 2 Low: 3 Neg: 0 | 27.20 ± 3.27 | 426 ± 45 | ||||||
5 | Combination of retinol and α-tocopherol for 7 days | 614 ± 156 | 20 ± 4 | High: 3 Low: 2 Neg: 0 | 43.00 ± 10.70 | High: 3 Low: 2 Neg: 0 | 40.60 ± 8.29 | 400 ± 83 | ||||||
6 | Retinol for 14 days (pre and post induction) | 599 ± 93 | 20 ± 5 | High: 3 Low: 2 Neg: 0 | 37.00 ± 3.53 | High:3 Low: 2 Neg: 0 | 44.80 ± 4.60 | 387 ± 81 | ||||||
7 | α -tocopherol for 14 days (pre and post alloxan induction) | 752 ± 190 | 27 ± 2 | High: 1 Low: 4 Neg: 0 | 38.60 ± 7.79 | High: 2 Low: 3 Neg: 0 | 32.40 ± 4.50 | 404 ± 66 | ||||||
8 | Combination of retinol and α-tocopherol for 14 days (pre and post alloxan induction) | 657 ± 78 | 25 ± 5 | High: 3 Low: 2 Neg: 0 | 48.20 ± 6.64 | High: 3 Low: 2 Neg: 0 | 41.40 ± 3.84 | 424 ± 52 |