Fig. 7

C1q Binds Photoreceptor Cell Synapses With Age or Retinal: Left images: Mice were aged from 3 to 24 months. Retinal sections were stained with anti-synaptophysin and anti-C1q (antibody 4.8, Abcam); Annexon, data on file. Right images: Balb/c mice were exposed to white light (28-29 k lux) for 4 h, and after an additional 20 h, retinal sections were prepared and stained with anti-C1q as above. Note C1q staining of both synapses (arrows) and infiltrating cells (asterisk); adjacent retinal section stained with bassoon (presynaptic marker: red) and IBA-1 (infiltrating macrophages or microglia: magenta). Note C1q overlap with synapses of the photoreceptor cells (arrows) in the OPL but not synapses within the IPL (arrow heads) [108]. Abbreviations, see figure.