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Table 4 Functional and structural outcomes in naïve and non-naïve (treated) eyes at 1 and 4 months

From: OCT biomarkers as predictors of visual improvement in diabetic macular edema eyes receiving dexamethasone implants

 

1 month (n = 33)

p-value

4 months (n = 33)

p-value

Naïve eyes (21)

Treated eyes (12)

Naïve eyes

(21)

Treated eyes.

(12)

CST µm, mean ± SD

331.9 ± 57.6

294.8 ± 64.0

0.098°

409.5 ± 133.7

354.0 ± 119.3

0.243°

CAT-3 mm µm, mean ± SD

358.8 ± 38.8

356.4 ± 44.9

0.877°

371.5 ± 115.3

390.6 ± 64.7

0.603°

CV-3 mm mm3, mean ± SD

2.54 ± 0.30

2.53 ± 0.30

0.985°

2.72 ± 0.59

2.75 ± 0.45

0.888°

SND, n (%)

2 (9.5%)

2 (16.7%)

0.610*

4 (19.1%)

4 (33.3%)

0.420*

ICS > 200 μm

20 (95.2%)

8 (66.7%)

0.047*

19 (90.5%)

10 (83.3%)

0.610*

DRIL, n (%)

11 (52.4%)

3 (25.0%)

0.160*

7 (33.3%)

2 (16.7%)

0.429*

SHF, n (%)

14 (66.7%)

7 (58.3%)

0.716*

15 (71.4%)

7 (58.3%)

0.471*

HF, n (%)

20 (95.2%)

10 (83.3%)

0.538*

18 (85.7%)

9 (75.0%)

0.643*

EZ/ELM alteration, n (%)

15 (71.4%)

8 (66.7%)

1.000*

11 (52.4%)

6 (50.0%)

1.000*

VMT, n (%)

3 (14.3%)

4 (33.3%)

0.377*

7 (33.3%)

2 (16.7%)

0.429*

  1. CAT: cube average thickness, CST: central subfoveal thickness, CV: cube volume, DRIL: disorganization of the inner retinal layers, EZ/ELM: ellipsoid zone/ external limiting membrane, ICS: Intraretinal Cystoid Spaces, IOP: intraocular pressure, HF: hyperreflective foci, SHF: Subfoveal hyperreflective foci, SND: Subfoveal neuroretinal detachment, VMT: vitreomacular traction. *Fischer’s exact test °Unpaired t-test