Table 1 Description of qRT-PCR Genes
Symbol | Gene Name | RefSeq Number | Function |
|---|---|---|---|
HIF1A | hypoxia inducible factor 1 subunit alpha | NM_001530 | This gene encodes the α subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia |
SOD2 | superoxide dismutase 2 | NM_000636 | A member of the iron/manganese superoxide dismutase family, this gene encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen |
VEGFA | Vascular endothelial growth factor A | NM_003376 | A member of the PDGF/VEGF growth factor family, this gene encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis |
HPRT1 | Hypoxanthine phosphoribosyltransferase 1 | NM_000194 | Transferase which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. Critical to generation of purine nucleotides through the purine salvage pathway. Endogenous control for QPCR |