Fig. 1

Optical Coherence Tomography (OCT) Illustration of Drusen and Reticular Pseudodrusen (RPD), A Color Fundus Photography depicts conventional drusen in the macular region and RPD positioned near the arcades. The OCT images correspond to the dashed lines on the fundus photography, with the third column displaying magnified views of the second column. B “Ribbon” RPD, hyperreflective material positioned above the retinal pigmented epithelium (RPE), leading to a modification in the contour of the ellipsoid zone (EZ). C Magnified view of area delineated by white dashed box, arrows indicate "Ribbon" RPD. D Conventional Drusen, located between the RPE and Bruch’s membrane. E Magnified view of area delineated by white dashed box, arrows indicate conventional Drusen. F “Dot” RPD, hyperreflective material penetrates through the EZ. G Magnified view of area delineated by white dashed box, arrows indicate "Dot" RPD. (Reprinted from Wu Z, Fletcher EL, Kumar H, Greferath U, Guymer RH. Reticular pseudodrusen: A critical phenotype in age-related macular degeneration. Progress in Retinal and Eye Research. 2022;88:101017, with permission from Elsevier)