Fig. 1

Processing pipeline of OCTA en-face images of the superior vascular complex (top row) and deep vascular plexus (bottom row) of a right eye (OD) with mild diabetic retinopathy. a Selected template 6 × 6 mm foveal centered image for registration reference b Averaged image after registration of 10 serially acquired images. c Deep Neural Network (DNN) vessel segmented image. d Pixel Intensity Coefficient of Variation colour map. Colour map values range from blue (no variation) to red (high variation), and were upper-end capped at 0.4 and subsequently remapped between 0 and 1 to yield a higher dynamic range