Fig. 2

A The 6 × 6 mm foveal centered Pixel Intensity Coefficient of Variation (PICoV) image of the superficial vascular complex for a right eye (OD) with mild diabetic retinopathy. B The 6 × 6 mm averaged OCTA image created from the same registered stack as panel A. C Magnification of panel A showing high temporal filling heterogeneity in the inner foveal avascular zone (FAZ) ring, while the surrounding capillary bed remains mostly static. D–E Registered image overlays of non-template SVC images, demonstrating registration efficacy. White overlay pixels denote common pixels shared between two images, while green and magenta overlay pixels denote pixels that differ in intensity between two images. Panel D is an overlay of panels F and G, while panel E is an overlay of panels F and H. F–H Individual OCTA images magnified to the FAZ region, illustrating how substantial intensity variation of individual capillaries manifest as high (red) PICoV signal in panels A and C. Magenta arrows indicate capillary segments featuring particularly high temporal variation relative to their surrounding vessels. Note how some FAZ capillaries are visible in one frame, while entirely absent in another