Table 2 Baseline characteristics of the included patients with tMH
Study (year) | Design | Number of patients | M/F ratio | Mean age | Follow-up | Macular hole width | Macular hole closure | Type of MH | Intervention | Clinical Treatment for Ocular Toxoplasmosis | Clinical Treatment in Postoperative |
|---|---|---|---|---|---|---|---|---|---|---|---|
Souza (2018) | Retrospective | 11 | 5/6 | 33.2 | 6 months | 165 ± 96 µm | 11/11 | tMH (11/11) | PPV + ILM + ERM (3/11); PPV + ILM (8/11) | NA | Postoperatively, all patients were prescribed moxifloxacin for 1 week and Pred Forte (prednisolone acetate 1%, Allergan) for 4 weeks, prophylactic TR treatment with trimethoprim/sulfamethoxazole (160/800 mg 3 times per week), and regularly followed up for at least 6 months |
Study (year) | Design | M:F | Age | Follow-up | Macular hole width | Macular hole closure | Type of MH | Intervention | Clinical Treatment for Ocular Toxoplasmosis | Clinical Treatment in Postoperative |
|---|---|---|---|---|---|---|---|---|---|---|
Erol (2021) | Case report | F | 30 | 2 months | 698 µm | Yes | FTMH | PPV | Trimethoprim/sulfamethoxazole (160/800 mg) twice a day and clindamycin 300 mg four times a day. After three days, 32 mg/day methylprednisolone was added to oral treatment | Drops containing antibiotics and steroids were applied for up to one month after surgery. Oral antibiotic treatment for toxoplasma was continued for six weeks |
Tanaka (2014) | Case report | M | 59 | 5 months | 2852 μm horizontally, 2571 μm vertically in spectral-domain OCT | No | FTMH | PPV + ILM + GAS | Oral acetylspiramycin (1200 mg/day) for 8 weeks | NA |
Arana (2012) | Case report | F | 35 | 8 months | NA | Yes | FTMH | PPV + GAS | Prednisolone and cycloplegic drops and empirical oral treatment with sulphamethoxazole (800 mg)/trimethoprim (160 mg) twice a day were started. Oral prednisone at 60 mg/day with tapering doses was added 2 days later for 8 weeks | NA |
Ikeda (2021) | Case report | M | 49 | 7 months | 500 μm | Yes | FTMH | PPV + ILM | 400 mg of sulfamethoxazole and 80 mg of trimethoprim orally. The oral prednisolone was also started from 30 mg and was tapered in 1 month. The treatment was continued for 6 weeks | NA |
Doshi (2020) | Case report | M | 34 | 4 weeks | NA | Yes | FTMH | Clinical | Sulphamethoxazole and trimethoprim (800 mg/160 mg) with oral prednisolone (1 mg/kg). As the lesion was very close to the fovea, the patient also received a single dose of intravitreal clindamycin 1 mg/0.1 ml along with dexamethasone 400 microgm/0.1 ml | NA |