Correlation between retinal sensitivity assessed by microperimetry and structural abnormalities on optical coherence tomography after successful epiretinal membrane surgery

Matos, Aline Mota Freitas; Defina, Raphael Lucas Sampaio; Costa-Cunha, Luciana Virgínia Ferreira; Zacharias, Leandro Cabral; Preti, Rony Carlos; Monteiro, Mário Luiz Ribeiro; Cunha, Leonardo Provetti

doi:10.1186/s40942-024-00542-8

International Journal of Retina and Vitreous

Table 2 Mean values of pre- and postoperative total macular thickness measurements (in µm) obtained by OCT in patients and controls, divided into nine sectors plus average thickness and macular volume, with the respective values of the areas under the ROC curve

From: Correlation between retinal sensitivity assessed by microperimetry and structural abnormalities on optical coherence tomography after successful epiretinal membrane surgery

OCT total macular thickness (µm)	Patients (n = 43)	Controls (n = 43)	p-value	AUC
Fovea
Pre-op	455.4 ± 67.2		< 0.001^a	0.99 (0.98–1.00)
Post-op	373.5 ± 58.7	241.1 ± 34.3	< 0.001^a	0.96 (0.91–1.00)
p-value	< 0.001^a
Temporal inner
Pre-op	419.9 ± 58.1		< 0.001^a	0.99 (0.97–1.00)
Post-op	328.9 ± 56.8	298.1 ± 16.1	0.001^a	0.73 (0.62–0.84)
p-value	< 0.001^a
Superior inner
Pre-op	427.9 ± 54.1		< 0.001^a	0.99 (0.98–1.00)
Post-op	344.5 ± 35.1	309.8 ± 17.1	< 0.001^a	0.83 (0.75–0.92)
p-value	< 0.001^a
Nasal inner
Pre-op	410.7 ± 52.8		< 0.001^a	0.94 (0.89–1.00)
Post-op	358.5 ± 36.2	310.6 ± 17.9	< 0.001^a	0.89 (0.81–0.96)
p-value	< 0.001^a
Inferior inner
Pre-op	397.1 ± 55.3		< 0.001^a	0.93 (0.88–0.99)
Post-op	334.7 ± 31.5	308.2 ± 20.5	< 0.001^a	0.76 (0.66–0.86)
p-value	< 0.001^a
Temporal outer
Pre-op	312.5 ± 51.8		< 0.001^a	0.90 (0.83–0.98)
Post-op	259.2 ± 27.1	254.4 ± 11.5	0.30	0.55 (0.43–0.68)
p-value	< 0.001^a
Superior outer
Pre-op	327.0 ± 42.7		< 0.001^a	0.91 (0.84–0.98)
Post-op	279.0 ± 29.4	269.4 ± 14.6	0.06	0.64 (0.52–0.76)
p-value	< 0.001^a
Nasal outer
Pre-op	328.4 ± 39.6		< 0.001^a	0.88 (0.80–0.95)
Post-op	286.9 ± 26.9	284.5 ± 15.2	0.61	0.53 (0.41–0.66)
p-value	< 0.001^a
Inferior outer
Pre-op	297.9 ± 45.5		< 0.001^a	0.76 (0.65–0.88)
Post-op	258.7 ± 24.7	259.8 ± 13.5	0.80	0.50 (0.38–0.63)
p-value	< 0.001^a
Average thickness
Pre-op	342.8 ± 33.6		< 0.001^a	0.97 (0.92–1.00)
Post-op	289.1 ± 23.1	275.1 ± 13.3	0.001^a	0.71 (0.60–0.82)
p-value	< 0.001^a
Macular volume
Pre-op	9.7 ± 0.9		< 0.001^a	0.97 (0.92–1.00)
Post-op	8.2 ± 0.6	7.8 ± 0.4	0.001^a	0.71 (0.60–0.82)
p-value	< 0.001^a

OCT Optical coherence tomography, AUC area under the ROC (receiver operating characteristic) curve
^aRepresents p < 0.05, by paired Student’s t-test (pre- versus post-surgery) and for independent samples (patients versus controls), pre-op: preoperative, post-op: postoperative

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ISSN: 2056-9920

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